Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Medicine and.
J Clin Invest. 2020 Mar 2;130(3):1084-1086. doi: 10.1172/JCI134696.
The human lipidome comprises over tens of thousands of distinct lipid species in addition to total cholesterol and the other conventional lipid traits that are routinely measurable in the peripheral circulation. Of the lipid species considered to exhibit bioactive functions, sphingolipids are a class of molecules that have shown relevance to human disease risk and cardiovascular outcomes in particular. In this issue of the JCI, Poss et al. conducted targeted lipidomics in a case-control study involving over 600 individuals and found a sphingolipid profile that predicted coronary artery disease status. In the context of emerging evidence linking sphingolipid biology with cardiovascular pathophysiology, these results suggest the potential utility of serum sphingolipids as cholesterol-independent markers of risk and even future targets for optimizing cardiovascular health.
人类脂质组学除了外周循环中常规可测量的总胆固醇和其他传统脂质特征外，还包含超过数万种不同的脂质种类。在被认为具有生物活性功能的脂质种类中，神经鞘脂是一类与人类疾病风险特别是心血管结局相关的分子。在本期 JCI 中，Poss 等人在一项涉及 600 多人的病例对照研究中进行了靶向脂质组学研究，发现了一种预测冠状动脉疾病状态的神经鞘脂谱。在将神经鞘脂生物学与心血管病理生理学联系起来的新证据背景下，这些结果表明血清神经鞘脂作为胆固醇独立的风险标志物甚至是优化心血管健康的未来靶点具有潜在的应用价值。
