Clinical significance of premenstrual dysphoric changes.

Women who report premenstrual dysphoric changes are more likely to have had prior (and are at increased risk for subsequent) episodes of major depressive disorder than are women who do not experience these changes. Women who are currently depressed tend to have premenstrual exacerbations or changes in their symptoms. During the premenstrual period, there is an increased likelihood of suicidal, aggressive, or impulsive behavior and for admission to a psychiatric facility. The authors discuss the possible influence of menstrual cycle phases on the evaluation and treatment of women by investigators and therapists.