Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Cell Calcium. 2020 Mar;86:102159. doi: 10.1016/j.ceca.2020.102159. Epub 2020 Jan 9.
In this brief review we discuss some aspects of the Na pump and its roles in mediating the effects of ouabain and endogenous ouabain (EO): i) in regulating the cytosolic Ca concentration ([Ca]) via Na/Ca exchange (NCX), and ii) in activating a number of protein kinase (PK) signaling cascades that control a myriad of cell functions. Importantly, [Ca] and the other signaling pathways intersect at numerous points because of the influence of Ca and calmodulin in modulating some steps in those other pathways. While both mechanisms operate in virtually all cells and tissues, this article focuses primarily on their functions in the cardiovascular system, the central nervous system (CNS) and the kidneys.
在这篇简要的综述中，我们讨论了钠泵及其在介导哇巴因和内源性哇巴因（EO）作用方面的一些作用：i）通过钠/钙交换（NCX）调节细胞浆 Ca 浓度 ([Ca])，以及 ii）激活许多蛋白激酶（PK）信号级联反应，从而控制无数的细胞功能。重要的是，由于 Ca 和钙调蛋白对这些其他途径中某些步骤的调节，[Ca]和其他信号通路在许多点相交。虽然这两种机制几乎在所有细胞和组织中都起作用，但本文主要关注它们在心血管系统、中枢神经系统（CNS）和肾脏中的功能。
