Bredesen Center for Interdisciplinary Research and Graduate Education, The University of Tennessee, Knoxville, TN, USA; Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, USA.
Bredesen Center for Interdisciplinary Research and Graduate Education, The University of Tennessee, Knoxville, TN, USA; Department of Chemical and Biomolecular Engineering, The University of Tennessee, Knoxville, TN, USA; Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN, USA.
Curr Opin Biotechnol. 2020 Feb;61:168-180. doi: 10.1016/j.copbio.2019.12.017. Epub 2020 Jan 25.
Esters constitute a large space of unique molecules with broad range of applications as flavors, fragrances, pharmaceuticals, cosmetics, green solvents, and advanced biofuels. Global demand of natural esters in food, household cleaner, personal care, and perfume industries is increasing while the ester supply from natural sources has been limited. Development of novel microbial cell factories for ester production from renewable feedstocks can potentially provide an alternative and sustainable source of natural esters and hence help fulfill growing demand. Here, we highlight recent advances in microbial production of esters and provide perspectives for improving its economic feasibility. As the field matures, microbial ester production platforms will enable renewable and sustainable production of flavors and fragrances, and open new market opportunities beyond what nature can offer.
酯类构成了一个庞大的独特分子空间，具有广泛的应用，如香料、香精、药物、化妆品、绿色溶剂和先进的生物燃料。天然酯在食品、家用清洁剂、个人护理和香水行业的全球需求正在增加，而天然来源的酯类供应一直有限。开发新型微生物细胞工厂，从可再生原料生产酯类，可能提供一种替代和可持续的天然酯类来源，并有助于满足不断增长的需求。在这里，我们重点介绍了微生物生产酯类的最新进展，并为提高其经济可行性提供了一些看法。随着该领域的成熟，微生物酯类生产平台将能够实现香料和香精的可再生和可持续生产，并开辟超越自然所能提供的新的市场机会。
