Jiang Mingyue, Liu Xue, Chen Zhijun, Li Jian, Liu Shouxin, Li Shujun
Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Northeast Forestry University, Hexing Road 26, Harbin 150040, P.R. China.
Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Northeast Forestry University, Hexing Road 26, Harbin 150040, P.R. China.
iScience. 2020 Feb 21;23(2):100832. doi: 10.1016/j.isci.2020.100832. Epub 2020 Jan 11.
Achieving efficient and biocompatible detachment between adhered wet materials (i.e., tissues and hydrogels) is a major challenge. Recently, photodetachable topological adhesion has shown great promise as a strategy for conquering this hurdle. However, this photodetachment was triggered by UV light with poor biocompatibility and penetration capacity. This study describes near-infrared (NIR) light-detached topological adhesion based on polyacrylic acid coated upconverting nanoparticles (UCNP@PAA) and a photodetachable adhesive (termed Cell-Fe). Cell-Fe is a coordinated topological adhesive consisting of carboxymethylcellulose and Fe that can be photodecomposed by UV light. To prepare a substrate for NIR-detached topological adhesion, UCNP@PAA and Cell-Fe were mixed and brushed on the surface of the model adherent. The UCNP@PAA can harvest NIR light and convert it into UV light, triggering the decomposition of the Cell-Fe and inducing the detachment. This NIR-detached topological adhesion is also feasible in deep tissue because of the ability of NIR light to penetrate tissue.
实现附着的湿材料（即组织和水凝胶）之间高效且生物相容的分离是一项重大挑战。最近，光可分离拓扑粘附作为克服这一障碍的策略已显示出巨大潜力。然而，这种光分离是由生物相容性和穿透能力较差的紫外光触发的。本研究描述了基于聚丙烯酸包覆的上转换纳米颗粒（UCNP@PAA）和光可分离粘合剂（称为Cell-Fe）的近红外（NIR）光分离拓扑粘附。Cell-Fe是一种由羧甲基纤维素和铁组成的配位拓扑粘合剂，可被紫外光光解。为了制备用于近红外分离拓扑粘附的基底，将UCNP@PAA和Cell-Fe混合并刷涂在模型粘附物表面。UCNP@PAA可以收集近红外光并将其转换为紫外光，触发Cell-Fe的分解并诱导分离。由于近红外光穿透组织的能力，这种近红外分离拓扑粘附在深部组织中也是可行的。
