Kim Jin Won, Park Seon-Young, Chung Jin Ook, Cho Hyun A, Kim Dong-Hyun, Yoon Jae Hyun, Park Chang Hwan, Kim Hyun Soo, Choi Sung Kyu, Rew Jong Sun
Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Divisions of Gastroenterology and Endocrinology, Chonnam National University Medical School, Gwangju, Korea.
Korean J Gastroenterol. 2020 Jan 25;75(1):23-28. doi: 10.4166/kjg.2020.75.1.23.
BACKGROUND/AIMS: This study aimed to identify the demographic and clinical factors associated with positive breath-test results and to assess the relationship between hydrogen and methane production in patients with suspected irritable bowel syndrome (IBS).
The demographic and clinical factors of 268 patients with suspected IBS, who had undergone a lactulose breath test, were analyzed.
Of 268 patients included in this study, 143 (53.4%) were females. The median age and BMI of the patients was 58.0 years (range, 18.0-80.0 years) and 22.5 kg/m (range, 14.4-34.3 kg/m), respectively. A weak positive correlation was observed between the BMI and baseline hydrogen level (rho=0.134, p=0.031). Women were significantly more likely to show a ≥20 ppm increase in hydrogen within 90 min (early hydrogen increase, p=0.049), a ≥10 ppm increase in methane within 90 min (early methane increase, p=0.001), and a ≥10 ppm increase in methane between 90 min and 180 min (late methane increase, p=0.002) compared to men. The baseline hydrogen level was related to the baseline methane level (rho=0.592, p<0.001) and the maximal hydrogen level within 90 min was related to maximal methane level within 90 min (rho=0.721, p<0.001). Patients with an early hydrogen increase (43.8%) were more likely to show a positive result for an early methane increase compared to patients without an early increase in hydrogen (0%, p<0.001).
Women were associated with high rates of positive lactulose breath-test results. In addition, methane production was correlated with hydrogen production.
背景/目的：本研究旨在确定与呼气试验阳性结果相关的人口统计学和临床因素，并评估疑似肠易激综合征（IBS）患者氢气和甲烷产生之间的关系。
分析了268例接受乳果糖呼气试验的疑似IBS患者的人口统计学和临床因素。
本研究纳入的268例患者中，143例（53.4%）为女性。患者的年龄中位数和BMI分别为58.0岁（范围18.0 - 80.0岁）和22.5 kg/m²（范围14.4 - 34.3 kg/m²）。BMI与基线氢气水平之间观察到弱正相关（rho = 0.134，p = 0.031）。与男性相比，女性在90分钟内氢气增加≥20 ppm（早期氢气增加，p = 0.049）、90分钟内甲烷增加≥10 ppm（早期甲烷增加，p = 0.001）以及90分钟至180分钟之间甲烷增加≥10 ppm（晚期甲烷增加，p = 0.002）的可能性显著更高。基线氢气水平与基线甲烷水平相关（rho = 0.592，p < 0.001），90分钟内的最大氢气水平与90分钟内的最大甲烷水平相关（rho = 0.721，p < 0.001）。与氢气无早期增加的患者相比，有早期氢气增加的患者（43.8%）更有可能出现早期甲烷增加的阳性结果（0%，p < 0.001）。
女性与乳果糖呼气试验阳性结果的高发生率相关。此外，甲烷产生与氢气产生相关。
