Bœuf Gaëlle, Roullin Gaëlle V, Moreau Juliette, Van Gulick Laurence, Zambrano Pineda Nebraska, Terryn Christine, Ploton Dominique, Andry Marie Christine, Chuburu Françoise, Dukic Sylvain, Molinari Michaël, Lemercier Gilles
ICMR-UMR CNRS no. 7312, Université de Reims Champagne-Ardenne, BP 1039-51687 Reims cedex 2 (France), Fax: (+33) (0)3-26-91-32-43.
Laboratoire de Recherche en Nanosciences, Université de Reims Champagne-Ardenne, BP 1039-51687 Reims cedex 2 (France).
Chempluschem. 2014 Jan;79(1):171-180. doi: 10.1002/cplu.201300242. Epub 2014 Jan 7.
The elaboration, characterisation and efficiency of potential two-photon-excited photodynamic therapy (PDT) treatment of new poly(d,l-lactide-co-glycolide) nanoparticles loaded with ruthenium(II) complexs are presented. The materials are based on the encapsulation of Ru complexes through an all-biocompatible process. The size of the nanoparticles is around 100 nm. The internal concentration is several orders of magnitude higher than the overall concentration, which leads to a more efficient and targeted effect. The therapeutic potential for PDT of these nanoparticles has been studied in vitro on C6 glioma cells.
本文介绍了负载钌（II）配合物的新型聚（d，l-丙交酯-共-乙交酯）纳米颗粒的潜在双光子激发光动力疗法（PDT）治疗的制备、表征及效果。这些材料是通过全生物相容的过程封装钌配合物制成的。纳米颗粒的尺寸约为100纳米。内部浓度比总体浓度高几个数量级，这导致了更有效和有针对性的效果。这些纳米颗粒在体外对C6胶质瘤细胞进行了光动力疗法的治疗潜力研究。
