Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Otolaryngol Head Neck Surg. 2020 Mar;162(3):337-342. doi: 10.1177/0194599820902387. Epub 2020 Jan 28.
Idiopathic sudden sensorineural hearing loss (ISSNHL) is a distressing condition that can significantly affect quality of life. Unilateral ISSNHL, occurring first in 1 ear and then the contralateral ear at a separate and discrete time, is a rare presentation that we refer to as . Our objective was to characterize the presentation of metachronous ISSNHL and report on management and hearing outcomes.
Retrospective case series.
Otology clinic at an academic tertiary referral center.
Patients ≥18 years old presenting with metachronous ISSNHL between April 2008 to November 2017 were identified through review of the clinic electronic medical record. Metachronous ISSNHL was defined as unilateral ISSNHL occurring in temporally discrete episodes (>6 months apart) affecting both ears. Patients with identifiable causes for sudden hearing loss were excluded. Patient demographics, comorbidities, management, and audiologic outcomes were recorded.
Eleven patients with metachronous ISSNHL were identified out of 558 patients with ISSNHL. In patients with metachronous ISSNHL, the mean ± standard deviation age at the time of ISSNHL in the second ear was 58.6 ± 15.2 years (range, 31-77 years). The mean interval between episodes was 9.6 ± 7.5 years (range, 1-22 years). Patients were treated with systemic and intratympanic steroids with variable hearing recovery; 5 patients with resultant bilateral severe to profound hearing loss underwent successful cochlear implantation.
Metachronous ISSNHL is uncommon. Treatment is similar to ISSNHL, and cochlear implantation can successfully restore hearing in individuals who do not experience recovery.
特发性突发性聋（ISSNHL）是一种令人痛苦的病症，会显著影响生活质量。单侧 ISSNHL 首先发生于 1 侧耳，然后在不同且离散的时间发生于对侧耳，这种罕见的表现我们称之为 。我们的目的是描述迟发性 ISSNHL 的表现，并报告其治疗和听力结果。
回顾性病例系列。
学术三级转诊中心的耳科诊所。
通过回顾诊所电子病历，确定了 2008 年 4 月至 2017 年 11 月期间出现迟发性 ISSNHL 的≥18 岁患者。迟发性 ISSNHL 定义为单侧 ISSNHL 以时间上离散的发作形式发生（间隔>6 个月），影响双耳。排除突发性听力损失有明确病因的患者。记录患者的人口统计学、合并症、治疗和听力结果。
在 558 例 ISSNHL 患者中，确定了 11 例迟发性 ISSNHL 患者。在迟发性 ISSNHL 患者中，第 2 耳 ISSNHL 的平均年龄±标准差为 58.6±15.2 岁（范围 31-77 岁）。发作之间的平均间隔为 9.6±7.5 年（范围 1-22 年）。患者接受了全身和鼓室内类固醇治疗，听力恢复情况不一；5 例患者因双侧严重至极重度听力损失而成功接受了人工耳蜗植入。
迟发性 ISSNHL 并不常见。治疗类似于 ISSNHL，对于未恢复听力的患者，人工耳蜗植入可以成功恢复听力。
