Toyo Institute of Food Technology, Kawanishi, Japan.
Biosci Biotechnol Biochem. 2020 May;84(5):1013-1022. doi: 10.1080/09168451.2020.1722608. Epub 2020 Jan 27.
In this study, I investigated the allergy suppressive effect of tea made from fig ( L.) leaves. In the rat basophil cell line RBL-2H3, degranulation was significantly suppressed by treatment with fig tea at the same time as addition of IgE antibodies (sensitization). IgE bound to the cell surface was liberated in the medium depending on the treatment time with fig tea. Therefore, it was suggested that the mechanism of action of fig tea is promotion of dissociation of IgE from FcεRI receptors. Such a mechanism is novel in food materials. On oral administration to mice, fig tea showed an inhibitory effect on allergic dermatitis. Furthermore, in tests using an atopic dermatitis model in NC/Nga mice, continued administration of fig tea suppressed symptom exacerbation after antigen administration. AD: atopic dermatitis; β-Hex: β-hexosaminidase; FCM: flow cytometory; OA: oral administration; TA: transdermal administration.
在这项研究中，我调查了由无花果（L.）叶制成的茶的抗过敏作用。在大鼠肥大细胞瘤系 RBL-2H3 中，与 IgE 抗体（致敏）同时添加时，无花果茶显著抑制脱颗粒。IgE 结合到细胞表面并根据无花果茶的处理时间释放到培养基中。因此，无花果茶的作用机制被认为是促进 IgE 从 FcεRI 受体解离。这种机制在食品材料中是新颖的。在给小鼠口服给药时，无花果茶显示出对过敏性皮炎的抑制作用。此外，在 NC/Nga 小鼠特应性皮炎模型的试验中，连续给予无花果茶可抑制抗原给药后的症状恶化。AD：特应性皮炎；β-Hex：β-己糖胺酶；FCM：流式细胞术；OA：口服给药；TA：经皮给药。
