Toyo Institute of Food Technology, 23-2, 4-Chome, Minami-Hanayashiki, Kawanishi 666-0026, Hyogo, Japan.
Nutrients. 2022 Oct 25;14(21):4470. doi: 10.3390/nu14214470.
Atopic dermatitis (AD) is a chronic, recurrent pruritic skin disease with repeated remissions and exacerbations. Various factors, such as allergies, skin conditions and lifestyle, combine to cause AD, making it difficult to cure completely. Although AD symptoms are suppressed with medications, this is a long-term effort and burden on patients. Thus, safer drugs and alternatives are needed. We previously found that consumption of tea prepared from fig ( L.) leaves alleviated allergy and AD symptoms in cultured cells and animals. Therefore, here, we conducted a double-blind, randomized, controlled study in patients with mild AD to evaluate the safety and AD-relieving effects of prolonged consumption of fig leaf tea. Positive effects of fig leaf tea consumption were confirmed in 14 of 15 participants. Eczema Area and Severity Index values were significantly lowered in the fig leaf tea-treated group than in the placebo-treated group. The effect weakened 4 weeks after the end of the intervention, suggesting that continued intake of fig leaf tea was effective. Further assessments confirmed the safety of fig leaf tea consumption and revealed no variations that might pose a health hazard. Therefore, we postulate that fig leaf tea is a natural and safe therapeutic option for AD.
特应性皮炎（AD）是一种慢性、复发性瘙痒性皮肤病，有反复发作和缓解的特点。过敏、皮肤状况和生活方式等各种因素共同作用导致 AD，使其难以完全治愈。尽管药物可以抑制 AD 症状，但这需要患者长期努力和承受负担。因此，需要更安全的药物和替代方法。我们之前发现，食用由无花果（L.）叶制成的茶可以减轻过敏和 AD 症状在培养细胞和动物中的作用。因此，在这里，我们在患有轻度 AD 的患者中进行了一项双盲、随机、对照研究，以评估长期饮用无花果叶茶的安全性和缓解 AD 的效果。在 15 名参与者中，有 14 名确认了无花果叶茶的积极作用。与安慰剂组相比，无花果叶茶治疗组的湿疹面积和严重程度指数（Eczema Area and Severity Index，EASI）显著降低。干预结束 4 周后，效果减弱，这表明持续摄入无花果叶茶是有效的。进一步的评估证实了无花果叶茶的安全性，没有发现可能对健康构成危害的变化。因此，我们推测无花果叶茶是 AD 的一种天然且安全的治疗选择。
