Montesano R, Orci L
Institute of Histology and Embryology, University of Geneva Medical Centre, Switzerland.
J Cell Sci. 1988 Mar;89 ( Pt 3):441-7. doi: 10.1242/jcs.89.3.441.
The endothelium of visceral capillaries is characterized by the occurrence of numerous fenestrae, which are usually bridged by a thin, single-layered diaphragm. Both in vivo and in vitro, diaphragmed fenestrae perforate the endothelial cell cytoplasm in the most attenuated regions of the cell. We report here that in capillary endothelial cells grown under experimental conditions promoting the development of intracellular lumina (for example, suspension within a three-dimensional collagen matrix), diaphragmed fenestrae can form in a unique, previously undescribed intracellular location - that is, within thin cytoplasmic septa separating contiguous luminal compartments.
内脏毛细血管的内皮细胞具有许多窗孔，这些窗孔通常由一层薄的单层隔膜所覆盖。在体内和体外，有隔膜的窗孔在细胞最薄的区域穿透内皮细胞质。我们在此报告，在促进细胞内管腔形成的实验条件下培养的毛细血管内皮细胞中（例如，悬浮在三维胶原基质中），有隔膜的窗孔可以在一个独特的、以前未描述过的细胞内位置形成，即在分隔相邻管腔间隔的薄细胞质隔内。
