Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan; Department of General Surgery, En Chu Kong Hospital, New Taipei, Taiwan.
Department of General Surgery, En Chu Kong Hospital, New Taipei, Taiwan.
Immunobiology. 2020 May;225(3):151906. doi: 10.1016/j.imbio.2020.151906. Epub 2020 Jan 22.
Dimethyl sulfoxide (DMSO) was discovered during the 19th century by the German chemical industry. DMSO comprises a highly polar group and two non-polar domains, which render it soluble in both aqueous solutions and organic solutions. Furthermore, DMSO can penetrate the cell membrane of both the mammalian cells and the non-mammalian cells and prevent freeze-thaw injuries to the cells. Thus, it is frequently used for the cryopreservation of cells and tissues for laboratory and clinical applications. In contrast to this traditional application, DMSO has recently been shown to possess immunomodulatory effects, such as immune enhancement, and anti-inflammatory effects in the innate immunity. In addition, DMSO also affects the adaptive immunity by regulating the expression of transcription factors in immune cells. This review briefly summarizes and highlights the roles and immunomodulatory effects of DMSO on the immune system and reveals the future clinical therapeutic potential of DMSO treatment in cancer, in autoimmune diseases and in chronic inflammatory diseases.
二甲基亚砜（DMSO）是 19 世纪由德国化学工业发现的。DMSO 由一个高度极性基团和两个非极性区域组成，这使得它既能溶于水溶液又能溶于有机溶剂。此外，DMSO 可以穿透哺乳动物细胞和非哺乳动物细胞的细胞膜，防止细胞的冻融损伤。因此，它经常被用于实验室和临床应用中的细胞和组织的冷冻保存。与这种传统应用相反，DMSO 最近被证明具有免疫调节作用，例如在先天免疫中增强免疫和抗炎作用。此外，DMSO 还通过调节免疫细胞中转录因子的表达来影响适应性免疫。这篇综述简要总结和强调了 DMSO 对免疫系统的作用和免疫调节作用，并揭示了 DMSO 在癌症、自身免疫性疾病和慢性炎症性疾病治疗方面的未来临床治疗潜力。
