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评论：一氧化氮：小儿心脏手术期间神经保护的重要贡献者。

Commentary: Nitric oxide: An important contributor to neuroprotection during pediatric cardiac surgery.

作者信息

Ishibashi Nobuyuki, Jonas Richard A

机构信息

Division of Cardiovascular Surgery, Center for Neuroscience Research, and Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC.

出版信息

J Thorac Cardiovasc Surg. 2021 Jun;161(6):e499-e500. doi: 10.1016/j.jtcvs.2019.12.057. Epub 2020 Jan 7.

DOI:10.1016/j.jtcvs.2019.12.057
PMID:31987614
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7538197/
Abstract

Animal studies are elucidating cellular mechanisms causing disturbed brain development in children with congenital heart disease, leading to new therapies, including application of nitric oxide.

摘要

动物研究正在阐明导致先天性心脏病患儿脑发育紊乱的细胞机制，从而带来新的治疗方法，包括一氧化氮的应用。

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Commentary: Nitric oxide: An important contributor to neuroprotection during pediatric cardiac surgery.评论：一氧化氮：小儿心脏手术期间神经保护的重要贡献者。
J Thorac Cardiovasc Surg. 2021 Jun;161(6):e499-e500. doi: 10.1016/j.jtcvs.2019.12.057. Epub 2020 Jan 7.
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[Inhaled nitric oxide: therapeutic applications in cardiac surgery].
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本文引用的文献

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Inhaled nitric oxide reduces injury and microglia activation in porcine hippocampus after deep hypothermic circulatory arrest.吸入一氧化氮可减轻深低温停循环后猪海马区的损伤和小胶质细胞激活。
J Thorac Cardiovasc Surg. 2021 Jun;161(6):e485-e498. doi: 10.1016/j.jtcvs.2019.12.075. Epub 2020 Jan 11.
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Prenatal hypoxemia alters microglial morphology in fetal sheep.产前低氧血症会改变胎羊小胶质细胞的形态。
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Cortical Dysmaturation in Congenital Heart Disease.先天性心脏病中的皮质发育不良。
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Neurodevelopmental Abnormalities and Congenital Heart Disease: Insights Into Altered Brain Maturation.神经发育异常与先天性心脏病：对大脑成熟改变的见解
Circ Res. 2017 Mar 17;120(6):960-977. doi: 10.1161/CIRCRESAHA.116.309048.
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Nitric oxide administration during paediatric cardiopulmonary bypass: a randomised controlled trial.一氧化氮在小儿体外循环中的应用：一项随机对照试验。
Intensive Care Med. 2016 Nov;42(11):1744-1752. doi: 10.1007/s00134-016-4420-6. Epub 2016 Sep 30.
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Prolonged White Matter Inflammation After Cardiopulmonary Bypass and Circulatory Arrest in a Juvenile Porcine Model.幼年猪模型中心肺转流和循环停止后白质的长期炎症反应
Ann Thorac Surg. 2015 Sep;100(3):1030-7. doi: 10.1016/j.athoracsur.2015.04.017. Epub 2015 Jul 27.
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Microglia: actively surveying and shaping neuronal circuit structure and function.小胶质细胞：主动检测和塑造神经元回路的结构和功能。
Trends Neurosci. 2013 Apr;36(4):209-17. doi: 10.1016/j.tins.2012.11.007. Epub 2012 Dec 20.
8
Nitric oxide delivery during cardiopulmonary bypass reduces postoperative morbidity in children--a randomized trial.体外循环期间给予一氧化氮输送可降低儿童术后发病率——一项随机试验。
J Thorac Cardiovasc Surg. 2013 Sep;146(3):530-6. doi: 10.1016/j.jtcvs.2012.09.100. Epub 2012 Dec 8.
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Cerebral metabolic recovery from deep hypothermic circulatory arrest after treatment with arginine and nitro-arginine methyl ester.精氨酸和硝基精氨酸甲酯治疗后深低温停循环后脑代谢的恢复
J Thorac Cardiovasc Surg. 1996 Sep;112(3):698-707. doi: 10.1016/S0022-5223(96)70054-5.