口服避孕药及生殖因素与多发性硬化症发病率的关系

Oral contraceptives and reproductive factors in multiple sclerosis incidence.

作者信息

Villard-Mackintosh L, Vessey M P

机构信息

Department of Public Health and Primary Care, Radcliffe Infirmary, Oxford, England.

出版信息

Contraception. 1993 Feb;47(2):161-8. doi: 10.1016/0010-7824(93)90088-o.

DOI:10.1016/0010-7824(93)90088-o

PMID:8449016

Abstract

Data from the Oxford.FPA prospective study show that oral contraceptive use and pregnancy have no discernible effect on the risk of developing multiple sclerosis (MS). Women of parity 0-2 developed MS twice as often as women of parity 3 or more but the difference did not reach statistical significance. Smoking may be a risk factor for developing MS. A nested case-control analysis did not identify any associations between MS onset and preceding illnesses.

摘要

牛津计划生育协会前瞻性研究的数据表明，使用口服避孕药和怀孕对患多发性硬化症（MS）的风险没有明显影响。生育次数为0 - 2次的女性患MS的几率是生育次数为3次或更多次女性的两倍，但这种差异未达到统计学显著性。吸烟可能是患MS的一个风险因素。一项巢式病例对照分析未发现MS发病与先前疾病之间存在任何关联。