Dental Materials Department, Baqai Dental College, Baqai Medical University, Karachi, Pakistan.
Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.
Photodiagnosis Photodyn Ther. 2020 Mar;29:101668. doi: 10.1016/j.pdpdt.2020.101668. Epub 2020 Jan 24.
This study was designed to investigate the clinical and microbiological parameters with photochemotherapy (PCT) against conventional debridement (CD) among patients with necrotizing ulcerative gingivitis (NUG).
Patients with a diagnosis of NUG were divided into two groups: 'Group-PCT' that underwent indocyanine green-mediated PCT with adjunctive mechanical debridement, and Group-CD that underwent mechanical debridement with adjunctive 3 % hydrogen peroxide/chlorhexidine rinse. Clinical inflammatory gingival parameters including full-mouth plaque scores (FMPS), bleeding scores (FMBS), and probing depth (PD) were measured. Counts of Treponema microdentium, Fusobacterium nucleatum and Prevotella intermedia were assessed using polymerase chain reaction technique. All assessments were done at baseline, 3 weeks and 6 weeks.
Twenty-six participants were contacted and agreed to participate in the trial. The mean age of participants in group-PCT was 24.5 years while the mean age of patients in group-CD was 26.7 years. FMPS showed significant but equal reduction in both the groups at 3 weeks and 6 weeks (p < 0.01). The reduction in mean FMBS was higher in the group-PCT at 6 weeks follow-up (p < 0.05). All bacterial levels reduced from baseline to follow-up with both PCT and CD groups (p < 0.05). Group-PCT showed significantly reduced counts of T. microdentium and F. nucleatum at 3 weeks and 6 weeks compared with group-CD (p = 0.024). Equal reduction was shown for P. intermedia between both the groups at 3 and 6 weeks, respectively.
Application of adjunctive photochemotherapy was both clinically and microbiologically effective in the treatment of NUG.
本研究旨在探讨针对坏死性溃疡性牙龈炎（NUG）患者，光化学疗法（PCT）与常规清创术（CD）相比的临床和微生物学参数。
将诊断为 NUG 的患者分为两组：“PCT 组”，接受吲哚菁绿介导的 PCT 联合辅助机械清创术；“CD 组”，接受机械清创术联合 3%过氧化氢/洗必泰冲洗。测量全口菌斑评分（FMPS）、出血评分（FMBS）和探诊深度（PD）等临床炎症性牙龈参数。使用聚合酶链反应技术评估微小密螺旋体、核梭杆菌和中间普氏菌的数量。所有评估均在基线、3 周和 6 周进行。
共联系了 26 名参与者，其中 26 名同意参加试验。PCT 组的平均年龄为 24.5 岁，而 CD 组的平均年龄为 26.7 岁。两组在 3 周和 6 周时 FMPS 均显著降低（p<0.01）。PCT 组在 6 周随访时 FMBS 的降低更为显著（p<0.05）。两组在 PCT 和 CD 组中，所有细菌水平均从基线降至随访时（p<0.05）。与 CD 组相比，PCT 组在 3 周和 6 周时 T. microdentium 和 F. nucleatum 的数量明显减少（p=0.024）。两组在 3 周和 6 周时 P. intermedia 的减少量相等。
辅助光化学疗法在治疗 NUG 方面具有临床和微生物学上的有效性。
