Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark.
Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Diabet Med. 2020 Dec;37(12):2098-2108. doi: 10.1111/dme.14251. Epub 2020 Feb 11.
To investigate the trends in non-traumatic lower limb amputation in people with and without diabetes.
From the Danish National Patient Register, all people with either type 1 or type 2 diabetes (n = 462 743) as well as a group of people without diabetes from the general population (n = 1 388 886) were identified and separated into three groups based on diabetes type. Among these, 17 265 amputations were identified between 1997 and 2017 and stratified into trans-femoral amputations, trans-tibial amputations and amputations below the ankle using surgical codes. Annual changes were described using least-squares linear regression.
The yearly mean decrease in incidence rate of amputation per 1000 person-years was -0.032 [95% CI: -0.062, -0.001], -0.022 [-0.032, -0.012] and -0.006 [-0.009, -0.003] for trans-femoral amputation, -0.072 [-0.093, -0.052], -0.090 [-0.102, -0.078] and -0.015 [-0.016, -0.013] for trans-tibial amputation, and -0.055 [-0.080, -0.020], -0.075 [-0.090, -0.060] and -0.011 [-0.014, -0.007] for amputation below the ankle in people with type 1 diabetes, people with type 2 diabetes and people without diabetes, respectively.
Over recent decades, the incidence of amputation has decreased significantly in people with diabetes and in the general population without diabetes.
调查有和没有糖尿病的人群中非创伤性下肢截肢的趋势。
从丹麦国家患者登记处确定所有 1 型或 2 型糖尿病患者（n=462743 人）以及一般人群中无糖尿病患者（n=138886 人），并根据糖尿病类型将他们分为三组。在这些患者中，1997 年至 2017 年间共确定了 17265 例截肢，并使用手术代码将其分为股骨截肢、胫骨截肢和踝以下截肢。使用最小二乘线性回归描述每年的变化。
每 1000 人年截肢发生率的年平均下降率分别为 -0.032[95%CI：-0.062，-0.001]、-0.022[-0.032，-0.012]和 -0.006[-0.009，-0.003]对于股骨截肢、-0.072[-0.093，-0.052]、-0.090[-0.102，-0.078]和 -0.015[-0.016，-0.013]对于胫骨截肢，以及-0.055[-0.080，-0.020]、-0.075[-0.090，-0.060]和 -0.011[-0.014，-0.007]对于 1 型糖尿病患者、2 型糖尿病患者和无糖尿病患者的踝以下截肢。
近几十年来，糖尿病患者和无糖尿病的一般人群中截肢的发病率显著下降。
