Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark.
Eur Arch Otorhinolaryngol. 2024 Feb;281(2):663-672. doi: 10.1007/s00405-023-08130-6. Epub 2023 Jul 29.
Diabetic neuropathy can lead to decreased peripheral sensation and motor neuron dysfunction associated with impaired postural control and risk of falling. However, the relationship between decreased peripheral sensation and impaired vestibular function in diabetes mellitus is poorly investigated. Therefore, the aim of this study was to investigate the relationship between peripheral and autonomic measurements of diabetic neuropathy and measurements of vestibular function.
A total of 114 participants with type 1 diabetes (n = 52), type 2 diabetes (n = 51) and controls (n = 11) were included. Vestibular function was evaluated by video head impulse testing. Peripheral neuropathy was assessed by quantitative sensory testing and nerve conduction. Autonomic neuropathy using the COMPASS 31 questionnaire. Data were analyzed according to data type and distribution.
Measurements of vestibular function did not differ between participants with type 1 diabetes, type 2 diabetes or controls (all p-values above 0.05). Subgrouping of participants according to the involvement of large-, small- or autonomic nerves did not change this outcome. Correlation analyses showed a significant difference between COMPASS 31 and right lateral gain value (ρ = 0.23, p = 0.02,), while no other significant correlations were found.
Diabetic neuropathy does not appear to impair vestibular function in diabetes, by means of the VOR.
NCT05389566, May 25th, 2022.
糖尿病性神经病可导致外周感觉减退和运动神经元功能障碍，与姿势控制受损和跌倒风险增加有关。然而，糖尿病患者外周感觉减退与前庭功能障碍之间的关系尚未得到充分研究。因此，本研究旨在探讨糖尿病性神经病的周围和自主神经测量与前庭功能测量之间的关系。
共纳入 114 名 1 型糖尿病（n=52）、2 型糖尿病（n=51）和对照组（n=11）患者。使用视频头脉冲测试评估前庭功能。通过定量感觉测试和神经传导评估周围神经病变。使用 COMPASS 31 问卷评估自主神经病变。根据数据类型和分布进行数据分析。
1 型糖尿病、2 型糖尿病和对照组患者的前庭功能测量值无差异（所有 p 值均大于 0.05）。根据大、小或自主神经受累情况对参与者进行亚组分析并未改变这一结果。相关性分析显示，COMPASS 31 与右侧横向增益值之间存在显著差异（ρ=0.23，p=0.02），而其他相关性均无统计学意义。
通过 VOR，糖尿病性神经病似乎不会损害糖尿病患者的前庭功能。
NCT05389566，2022 年 5 月 25 日。
