UQ Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, Australia.
Centre in Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia.
Tissue Eng Part A. 2020 Mar;26(5-6):305-317. doi: 10.1089/ten.TEA.2019.0278. Epub 2020 Feb 26.
Three-dimensional (3D)-engineered scaffolds have been widely investigated as drug delivery systems (DDS) or cancer models with the aim to develop effective cancer therapies. The and models developed via 3D printing (3DP) and tissue engineering concepts have significantly contributed to our understanding of cell-cell and cell-extracellular matrix interactions in the cancer microenvironment. Moreover, 3D tumor models were used to study the therapeutic efficiency of anticancer drugs. The present study aims to provide an overview of applying the 3DP and tissue engineering concepts for cancer studies with suggestions for future research directions. The 3DP technologies being used for the fabrication of personalized DDS have been highlighted and the potential technical approaches and challenges associated with the fused deposition modeling, the inkjet-powder bed, and stereolithography as the most promising 3DP techniques for drug delivery purposes are briefly described. Then, the advances, challenges, and future perspectives in tissue-engineered cancer models for precision medicine are discussed. Overall, future advances in this arena depend on the continuous integration of knowledge from cancer biology, biofabrication techniques, multiomics and patient data, and medical needs to develop effective treatments ultimately leading to improved clinical outcomes. Impact statement Three-dimensional printing (3DP) enables the fabrication of personalized medicines and drug delivery systems. The convergence of 3DP, tissue engineering concepts, and cancer biology could significantly improve our understanding of cancer biology and contribute to the development of new cancer therapies.
三维（3D）工程支架已被广泛研究作为药物输送系统（DDS）或癌症模型，旨在开发有效的癌症治疗方法。通过 3D 打印（3DP）和组织工程概念开发的 和 模型，极大地促进了我们对癌症微环境中细胞-细胞和细胞-细胞外基质相互作用的理解。此外，3D 肿瘤模型被用于研究抗癌药物的治疗效果。本研究旨在概述应用 3DP 和组织工程概念进行癌症研究，并为未来的研究方向提出建议。突出了用于制造个性化 DDS 的 3DP 技术，并简要描述了与融合沉积建模、喷墨粉末床和立体光刻相关的潜在技术方法和挑战，这些技术是最有前途的用于药物输送目的的 3DP 技术。然后，讨论了用于精准医学的组织工程癌症模型的进展、挑战和未来展望。总的来说，该领域的未来进展取决于癌症生物学、生物制造技术、多组学和患者数据以及医疗需求的知识不断融合，以开发有效的治疗方法，最终导致临床结果的改善。影响说明 3D 打印（3DP）能够制造个性化药物和药物输送系统。3DP、组织工程概念和癌症生物学的融合可能会极大地促进我们对癌症生物学的理解，并有助于开发新的癌症治疗方法。
