3D打印微针阵列材料的进展：提高性能和生物相容性
Advancements in Materials for 3D-Printed Microneedle Arrays: Enhancing Performance and Biocompatibility.
作者信息
Razzaghi Mahmood, Alexander Ninan Joel, Akbari Mohsen
机构信息
Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
Terasaki Institute for Biomedical Innovations, Los Angeles, CA 90050, USA.
出版信息
Micromachines (Basel). 2024 Nov 28;15(12):1433. doi: 10.3390/mi15121433.
The rapid advancement of 3D printing technology has revolutionized the fabrication of microneedle arrays (MNAs), which hold great promise in biomedical applications such as drug delivery, diagnostics, and therapeutic interventions. This review uniquely explores advanced materials used in the production of 3D-printed MNAs, including photopolymer resins, biocompatible materials, and composite resins, designed to improve mechanical properties, biocompatibility, and functional performance. Additionally, it introduces emerging trends such as 4D printing for programmable MNAs. By analyzing recent innovations, this review identifies critical challenges and proposes future directions to advance the field of 3D-printed MNAs. Unlike previous reviews, this paper emphasizes the integration of innovative materials with advanced 3D printing techniques to enhance both the performance and sustainability of MNAs.
3D打印技术的快速发展彻底改变了微针阵列（MNAs）的制造方式，微针阵列在药物递送、诊断和治疗干预等生物医学应用中具有巨大潜力。本综述独特地探讨了用于生产3D打印微针阵列的先进材料，包括光聚合物树脂、生物相容性材料和复合树脂，这些材料旨在改善机械性能、生物相容性和功能性能。此外，还介绍了诸如用于可编程微针阵列的4D打印等新兴趋势。通过分析近期的创新成果，本综述确定了关键挑战，并提出了推进3D打印微针阵列领域发展的未来方向。与以往的综述不同，本文强调将创新材料与先进的3D打印技术相结合，以提高微针阵列的性能和可持续性。
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