Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Vaccine. 2020 Feb 24;38(9):2117-2121. doi: 10.1016/j.vaccine.2020.01.048. Epub 2020 Jan 25.
Japanese encephalitis (JE) is a rare but potentially severe disease among travelers. JE vaccine in the United States costs $500-$600 for a 2-dose series and is safe and effective but rare serious adverse events can occur. Our survey investigated likelihood of vaccine receipt for travel.
An electronically-administered survey was conducted among U.S. adults. Participants were presented a hypothetical scenario on travel to a JE-endemic country and JE vaccine characteristics and responded on likelihood of vaccination.
Overall, 6384 (59%) of 10,904 persons completed the questions. Population estimates indicated 32% would be likely and 42% were unlikely to be vaccinated, and 26% were unsure. Among those likely to get vaccinated, important factors were disease risk and severity, and vaccine safety. Among those unlikely, cost, disease risk, and possibility of serious side effects ranked highest.
There is population heterogeneity in perception of JE disease risk and value of vaccination.
日本脑炎（JE）在旅行者中较为罕见，但具有潜在严重性。美国的 JE 疫苗两针系列价格为 500-600 美元，安全有效，但也可能出现罕见的严重不良反应。我们的调查研究了旅行者接种疫苗的可能性。
在美国成年人中进行了电子问卷调查。参与者被提供了一个前往 JE 流行国家旅行的假设情景和 JE 疫苗的特征，并对接种疫苗的可能性进行了回答。
总体而言，10904 名参与者中有 6384 名（59%）完成了问题。人口估计表明，32%的人可能接种，42%的人不太可能接种，26%的人不确定。在那些可能接种疫苗的人中，重要的因素是疾病风险和严重程度，以及疫苗的安全性。在那些不太可能接种疫苗的人中，费用、疾病风险和严重副作用的可能性是最重要的因素。
人们对 JE 疾病风险和疫苗接种价值的看法存在群体异质性。
