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哺乳期使用大麻:文献综述与临床建议

Cannabis Use During Lactation: Literature Review and Clinical Recommendations.

作者信息

Ordean Alice, Kim Gloria

机构信息

Department of Family Medicine, St. Joseph's Health Centre, Unity Health, Toronto, ON; Department of Family and Community Medicine, University of Toronto, Toronto, ON.

Faculty of Health Sciences, McMaster University, Hamilton, ON.

出版信息

J Obstet Gynaecol Can. 2020 Oct;42(10):1248-1253. doi: 10.1016/j.jogc.2019.11.003. Epub 2020 Jan 25.

Abstract

Cannabis is the most commonly used psychoactive substance in Canada. The prevalence of cannabis use both during pregnancy and in the postpartum period has been estimated at 5% of the population. Women who use the drug during lactation place their infants at risk of exposure to cannabis and its metabolites in breast milk. This article provides a systematic review of infant outcomes associated with cannabis use by women during lactation followed by clinical recommendations. A review of the literature was conducted using Medline, Embase, and PsychInfo from their start to July 2018. Inclusion criteria consisted of articles addressing the impact of postpartum cannabis use by lactating women and providing developmental outcomes for infants. Two articles met these criteria and were included in our systematic review. Results indicate conflicting outcomes regarding the risk of exposure to cannabis in breast milk. Women should be advised to abstain from cannabis use during lactation or reduce consumption if abstinence is not possible. Furthermore, women should be advised to avoid breastfeeding within 1 hour of inhaled use to reduce exposure to highest concentration of cannabis in breast milk. Despite some evidence regarding health risks of post-natal exposure to cannabis, further research is needed to determine its impact on infant neurodevelopmental outcomes beyond the first year of life.

摘要

大麻是加拿大最常用的精神活性物质。据估计,孕期和产后使用大麻的人口比例为5%。哺乳期使用该药物的女性会使其婴儿面临通过母乳接触大麻及其代谢物的风险。本文对哺乳期女性使用大麻与婴儿结局的相关研究进行了系统综述,并给出了临床建议。我们使用Medline、Embase和PsychInfo数据库,检索了从建库至2018年7月的文献。纳入标准包括探讨哺乳期女性产后使用大麻的影响并提供婴儿发育结局的文章。有两篇文章符合这些标准并被纳入我们的系统综述。结果表明,关于母乳中接触大麻的风险存在相互矛盾的结果。应建议女性在哺乳期避免使用大麻,若无法戒除则应减少用量。此外,应建议女性在吸入大麻后1小时内避免母乳喂养,以减少接触母乳中最高浓度的大麻。尽管有一些证据表明产后接触大麻存在健康风险,但仍需进一步研究以确定其对婴儿一岁以后神经发育结局的影响。

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