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妊娠急性脂肪肝:罕见,但可能致命。

Acute Fatty Liver of Pregnancy: Rare, but Potentially Fatal.

作者信息

de Vasconcelos Gaspar Andreia, Ascensão Tânia C, Santos Silva Isabel

机构信息

Obstetrics Service B, Bissaya Barreto Maternity, Coimbra University and Hospital Center, Coimbra, Portugal.

出版信息

Am J Case Rep. 2020 Jan 29;21:e921122. doi: 10.12659/AJCR.921122.

DOI:10.12659/AJCR.921122
PMID:31992686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7006598/
Abstract

BACKGROUND Acute fatty liver of pregnancy is an obstetric emergency characterized by liver dysfunction, which can lead to severe maternal and fetal complications. CASE REPORT A 34-year-old woman, 37 weeks and 2 days pregnant, reported symptoms of nausea, vomiting, jaundice, and prostration. Laboratory findings revealed liver dysfunction and coagulopathy. A clinical diagnosis of acute fatty liver was made and an emergency cesarean section was performed. The postoperative period was complicated by disseminated intravascular coagulation, acute hepatic and renal insufficiency, and pancreatitis. CONCLUSIONS Early recognition of this pathology, the interruption of pregnancy, and intensive therapy led to a favorable outcome.

摘要

背景

妊娠急性脂肪肝是一种以肝功能障碍为特征的产科急症,可导致严重的母婴并发症。病例报告:一名34岁女性,孕37周零2天,出现恶心、呕吐、黄疸和虚脱症状。实验室检查结果显示肝功能障碍和凝血功能障碍。临床诊断为急性脂肪肝,并进行了急诊剖宫产。术后出现弥散性血管内凝血、急性肝肾功能不全和胰腺炎等并发症。结论:对该病症的早期识别、终止妊娠以及强化治疗带来了良好的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b41e/7006598/2aeae556f8b1/amjcaserep-21-e921122-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b41e/7006598/2aeae556f8b1/amjcaserep-21-e921122-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b41e/7006598/2aeae556f8b1/amjcaserep-21-e921122-g001.jpg

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A 24-Year-Old Woman Presenting in the Third Trimester of Pregnancy with Nausea, Vomiting, and Abdominal Pain and Diagnosed with Acute Fatty Liver of Pregnancy.一位 24 岁的孕妇在妊娠晚期出现恶心、呕吐和腹痛,并被诊断为妊娠急性脂肪肝。
Am J Case Rep. 2022 Aug 24;23:e937085. doi: 10.12659/AJCR.937085.
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Acute Fatty Liver of Pregnancy.

本文引用的文献

1
Acute Fatty Liver Disease of Pregnancy: Updates in Pathogenesis, Diagnosis, and Management.妊娠急性脂肪肝:发病机制、诊断及管理的最新进展
Am J Gastroenterol. 2017 Jun;112(6):838-846. doi: 10.1038/ajg.2017.54. Epub 2017 Mar 14.
2
The Epidemiology of Liver Diseases Unique to Pregnancy in a US Community: A Population-Based Study.美国一个社区妊娠期特发性肝病的流行病学:一项基于人群的研究。
Clin Gastroenterol Hepatol. 2016 Feb;14(2):287-94.e1-2. doi: 10.1016/j.cgh.2015.08.022. Epub 2015 Aug 21.
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Retrospective study of seven cases with acute Fatty liver of pregnancy.
妊娠急性脂肪肝。
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A prospective national study of acute fatty liver of pregnancy in the UK.英国一项关于妊娠急性脂肪肝的前瞻性全国性研究。
Gut. 2008 Jul;57(7):951-6. doi: 10.1136/gut.2008.148676. Epub 2008 Mar 10.
8
Pregnancy-associated liver disorders.妊娠相关肝脏疾病
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[Recurrent acute fatty liver of pregnancy].[复发性妊娠急性脂肪肝]
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Acute fatty liver of pregnancy associated with pancreatitis: a life-threatening complication.妊娠急性脂肪肝合并胰腺炎:一种危及生命的并发症。
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