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本文引用的文献

1
Frailty syndrome: an overview.衰弱综合征：概述。
Clin Interv Aging. 2014 Mar 19;9:433-41. doi: 10.2147/CIA.S45300. eCollection 2014.

线粒体根源导致加速衰老和虚弱。

A mitochondrial root to accelerated ageing and frailty.

机构信息

National Institute on Aging, National Institute of Health, Baltimore, MD, USA.

出版信息

Nat Rev Endocrinol. 2020 Mar;16(3):133-134. doi: 10.1038/s41574-020-0319-y.

DOI:10.1038/s41574-020-0319-y
PMID:31992872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7462101/
Abstract

A discovery metabolomic study was performed in a large cohort of adults to identify circulating biomarkers of frailty. The study found that carnitine and vitamin E pathways were dysregulated in frail compared with non-frail participants. These findings point to dysregulated mitochondrial metabolism as a potential root of age-related frailty.

摘要

一项基于大样本成年人的代谢组学研究旨在寻找易导致身体虚弱的生物标志物。研究发现与非虚弱参与者相比，肉碱和维生素 E 代谢途径在虚弱者体内失调。这些发现表明，线粒体代谢失调可能是与年龄相关的虚弱的潜在根源。