• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Aberrant non-canonical WNT pathway as key-driver of high-grade serous ovarian cancer development.

作者信息

Zannoni Gian Franco, Angelico Giuseppe, Santoro Angela

机构信息

Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Unità di Gineco-patologia e Patologia Mammaria, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go Francesco Vito, 1, 00168, Rome, Italy.

Istituto di Anatomia Patologica, Università Cattolica del Sacro Cuore, Rome, Italy.

出版信息

Virchows Arch. 2020 Aug;477(2):321-322. doi: 10.1007/s00428-020-02760-5. Epub 2020 Jan 28.

DOI:10.1007/s00428-020-02760-5
PMID:31993773
Abstract
摘要

相似文献

1
Aberrant non-canonical WNT pathway as key-driver of high-grade serous ovarian cancer development.异常的非经典WNT信号通路是高级别浆液性卵巢癌发生发展的关键驱动因素。
Virchows Arch. 2020 Aug;477(2):321-322. doi: 10.1007/s00428-020-02760-5. Epub 2020 Jan 28.
2
Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis.Wnt/β-catenin 信号通路在卵巢癌中的作用：过度激活及其在肿瘤发生中的功能。
J Ovarian Res. 2019 Dec 11;12(1):122. doi: 10.1186/s13048-019-0596-z.
3
ALPL regulates the aggressive potential of high grade serous ovarian cancer cells via a non-canonical WNT pathway.ALPL 通过非经典 WNT 通路调节高级别浆液性卵巢癌细胞的侵袭潜能。
Biochem Biophys Res Commun. 2019 May 28;513(2):528-533. doi: 10.1016/j.bbrc.2019.04.016. Epub 2019 Apr 9.
4
The non-canonical Wnt ligand, Wnt5a, is upregulated and associated with epithelial to mesenchymal transition in epithelial ovarian cancer.非经典Wnt配体Wnt5a在卵巢上皮癌中上调，并与上皮-间质转化相关。
Gynecol Oncol. 2014 Aug;134(2):338-45. doi: 10.1016/j.ygyno.2014.06.004. Epub 2014 Jun 10.
5
Dishevelled family proteins in serous ovarian carcinomas: a clinicopathologic and molecular study.在浆液性卵巢癌中蓬乱蛋白家族：一项临床病理和分子研究。
APMIS. 2020 Mar;128(3):201-210. doi: 10.1111/apm.13012. Epub 2020 Jan 28.
6
Critical role of Wnt/β-catenin signaling in driving epithelial ovarian cancer platinum resistance.Wnt/β-连环蛋白信号通路在驱动上皮性卵巢癌铂耐药中的关键作用。
Oncotarget. 2015 Sep 15;6(27):23720-34. doi: 10.18632/oncotarget.4690.
7
Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway and TP53-mutant tumors and identifies NRAS as an oncogenic driver.具有交界性分化的浆液性卵巢癌的基因组分类可区分 RAS 通路和 TP53 突变型肿瘤，并确定 NRAS 为致癌驱动基因。
Clin Cancer Res. 2014 Dec 15;20(24):6618-30. doi: 10.1158/1078-0432.CCR-14-1292. Epub 2014 Oct 14.
8
Methylation-associated silencing of SFRP1 gene in high-grade serous ovarian carcinomas.高级别浆液性卵巢癌中SFRP1基因的甲基化相关沉默
Ann Diagn Pathol. 2017 Dec;31:45-49. doi: 10.1016/j.anndiagpath.2017.07.002. Epub 2017 Jul 15.
9
Prolactin signaling drives tumorigenesis in human high grade serous ovarian cancer cells and in a spontaneous fallopian tube derived model.催乳素信号驱动人高级别浆液性卵巢癌细胞和自发输卵管衍生模型中的肿瘤发生。
Cancer Lett. 2018 Oct 1;433:221-231. doi: 10.1016/j.canlet.2018.07.003. Epub 2018 Jul 5.
10
B7-H4 expression in ovarian serous carcinoma: a study of 306 cases.B7-H4在卵巢浆液性癌中的表达：306例研究
Hum Pathol. 2016 Nov;57:1-6. doi: 10.1016/j.humpath.2016.06.011. Epub 2016 Jun 24.

引用本文的文献

1
Decoding β-catenin expression patterns in ovarian serous carcinoma with clinicopathological implications: insights from National Cancer Institute.解读卵巢浆液性癌中β-连环蛋白表达模式及其临床病理意义：来自美国国立癌症研究所的见解
Clin Transl Oncol. 2025 Jun;27(6):2461-2466. doi: 10.1007/s12094-024-03770-4. Epub 2024 Nov 13.
2
New insights for gynecological cancer therapies: from molecular mechanisms and clinical evidence to future directions.妇科癌症治疗的新见解：从分子机制和临床证据到未来方向。
Cancer Metastasis Rev. 2023 Sep;42(3):891-925. doi: 10.1007/s10555-023-10113-2. Epub 2023 Jun 27.
3
WISP1 induces ovarian cancer via the IGF1/αvβ3/Wnt axis.

本文引用的文献

1
WNT pathway in oral cancer: epigenetic inactivation of WNT-inhibitors.口腔癌中的 WNT 通路：WNT 抑制剂的表观遗传失活。
Oncol Rep. 2010 Oct;24(4):1035-41. doi: 10.3892/or.2010.1035.
WISP1 通过 IGF1/αvβ3/Wnt 轴诱导卵巢癌。
J Ovarian Res. 2022 Aug 13;15(1):94. doi: 10.1186/s13048-022-01016-x.
4
Current Prognostic and Predictive Biomarkers for Endometrial Cancer in Clinical Practice: Recommendations/Proposal from the Italian Study Group.子宫内膜癌临床实践中当前的预后和预测生物标志物：来自意大利研究小组的建议/提案
Front Oncol. 2022 Apr 8;12:805613. doi: 10.3389/fonc.2022.805613. eCollection 2022.
5
Prognostic Value of Chemotherapy Response Score (CRS) Assessed on the Adnexa in Ovarian High-Grade Serous Carcinoma: A Systematic Review and Meta-Analysis.附件评估的化疗反应评分（CRS）对卵巢高级别浆液性癌的预后价值：一项系统评价和荟萃分析
Diagnostics (Basel). 2022 Mar 4;12(3):633. doi: 10.3390/diagnostics12030633.
6
Recent Advances in Ovarian Cancer: Therapeutic Strategies, Potential Biomarkers, and Technological Improvements.卵巢癌的最新进展：治疗策略、潜在生物标志物和技术改进。
Cells. 2022 Feb 13;11(4):650. doi: 10.3390/cells11040650.
7
New Pathological and Clinical Insights in Endometrial Cancer in View of the Updated ESGO/ESTRO/ESP Guidelines.基于更新后的ESGO/ESTRO/ESP指南看子宫内膜癌的新病理及临床见解
Cancers (Basel). 2021 May 26;13(11):2623. doi: 10.3390/cancers13112623.
8
An Emerging Anti-p16 Antibody-BC42 Clone as an Alternative to the Current E6H4 for Use in the Female Genital Tract Pathological Diagnosis: Our Experience and a Review on p16ink4a Functional Significance, Role in Daily-Practice Diagnosis, Prognostic Potential, and Technical Pitfalls.一种新兴的抗p16抗体-BC42克隆作为当前E6H4的替代品用于女性生殖道病理诊断：我们的经验以及关于p16ink4a功能意义、在日常诊断中的作用、预后潜力和技术陷阱的综述
Diagnostics (Basel). 2021 Apr 16;11(4):713. doi: 10.3390/diagnostics11040713.
9
Evaluation of Beta-Catenin Subcellular Localization and Water Channel Protein AQP1 Expression as Predictive Markers of Chemo-Resistance in Ovarian High-Grade Serous Carcinoma: Comparative Study between Preoperative Peritoneal Biopsies and Surgical Samples.评估β-连环蛋白亚细胞定位和水通道蛋白AQP1表达作为高级别浆液性卵巢癌化疗耐药预测标志物的研究：术前腹膜活检与手术样本的比较研究
Diagnostics (Basel). 2021 Mar 5;11(3):452. doi: 10.3390/diagnostics11030452.
10
Phytochemicals in Gynecological Cancer Prevention.妇科癌症预防中的植物化学物。
Int J Mol Sci. 2021 Jan 26;22(3):1219. doi: 10.3390/ijms22031219.