Santoro Angela, Angelico Giuseppe, Travaglino Antonio, Inzani Frediano, Arciuolo Damiano, Valente Michele, D'Alessandris Nicoletta, Scaglione Giulia, Fiorentino Vincenzo, Raffone Antonio, Zannoni Gian Franco
Unità di Ginecopatologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Roma, Italy.
Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, 80131 Naples, Italy.
Cancers (Basel). 2021 May 26;13(11):2623. doi: 10.3390/cancers13112623.
Endometrial carcinoma represents the most common gynecological cancer in Europe and the USA. Histopathological classification based on tumor morphology and tumor grade has played a crucial role in the management of endometrial carcinoma, allowing a prognostic stratification into distinct risk categories, and guiding surgical and adjuvant therapy. In 2013, The Cancer Genome Atlas (TCGA) Research Network reported a large scale molecular analysis of 373 endometrial carcinomas which demonstrated four categories with distinct clinical, pathologic, and molecular features: POLE/ultramutated (7% of cases) microsatellite instability (MSI)/hypermutated (28%), copy-number low/endometrioid (39%), and copy-number high/serous-like (26%). In the present article, we report a detailed histological and molecular review of all endometrial carcinoma histotypes in light of the current ESGO/ESTRO/ESP guidelines. In particular, we focus on the distribution and prognostic value of the TCGA groups in each histotype.
子宫内膜癌是欧洲和美国最常见的妇科癌症。基于肿瘤形态和肿瘤分级的组织病理学分类在子宫内膜癌的管理中发挥了关键作用，可将预后分层为不同的风险类别，并指导手术和辅助治疗。2013年，癌症基因组图谱（TCGA）研究网络报告了对373例子宫内膜癌的大规模分子分析，结果显示出具有不同临床、病理和分子特征的四类：POLE/超突变型（7%的病例）、微卫星不稳定（MSI）/高突变型（28%）、拷贝数低/子宫内膜样型（39%）和拷贝数高/浆液性样型（26%）。在本文中，我们根据当前的ESGO/ESTRO/ESP指南，报告了对所有子宫内膜癌组织学类型的详细组织学和分子学综述。特别是，我们重点关注TCGA各分组在每种组织学类型中的分布及预后价值。
