正反馈和负反馈机制在发芽血管生成过程中控制尖端/干细胞的特性。
Positive and negative feedback mechanisms controlling tip/stalk cell identity during sprouting angiogenesis.
机构信息
Sanquin Research and Landsteiner Laboratory, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands.
出版信息
Angiogenesis. 2020 May;23(2):75-77. doi: 10.1007/s10456-020-09706-0.
Vascular endothelial growth factor-A (VEGF-A/VEGF) interaction with VEGF receptor 2 (VEGFR2) is key for sprouting angiogenesis in health and disease. VEGF/VEGFR2 signaling promotes endothelial proliferation and migration, as well as the hierarchical organization into leader (tip) and follower (stalk) cells via a dynamic interplay with Notch. Recent studies reveal novel molecular mechanisms to fine-tune VEGF/Notch signaling and tip/stalk cell function during sprouting angiogenesis.
血管内皮生长因子-A（VEGF-A/VEGF）与血管内皮生长因子受体 2（VEGFR2）的相互作用是健康和疾病中血管生成的关键。VEGF/VEGFR2 信号通路通过与 Notch 的动态相互作用促进内皮细胞的增殖和迁移，以及层次组织成领导者（尖端）和追随者（干）细胞。最近的研究揭示了新的分子机制，可在血管生成过程中精细调节 VEGF/Notch 信号和尖端/干细胞功能。
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