Adams Kenneth F, Leitzmann Michael F, Albanes Demetrius, Kipnis Victor, Moore Steven C, Schatzkin Arthur, Chow Wong-Ho
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA.
Am J Epidemiol. 2008 Aug 1;168(3):268-77. doi: 10.1093/aje/kwn122. Epub 2008 Jun 9.
Renal cell cancer (RCC) incidence has increased in the United States over the past three decades. The authors analyzed the association between body mass index (BMI) and invasive RCC in the National Institutes of Health (NIH)-AARP Diet and Health Study, a large, prospective cohort aged 50-71 years at baseline initiated in 1995-1996, with follow-up through December 2003. Detailed analyses were conducted in a subcohort responding to a second questionnaire, including BMI at younger ages (18, 35, and 50 years); weight change across three consecutive age intervals; waist, hip, and waist-to-hip ratio; and height at age 18 years. Incident RCC was diagnosed in 1,022 men and 344 women. RCC was positively and strongly related to BMI at study baseline. Among subjects analyzed in the subcohort, RCC associations were strongest for baseline BMI and BMI recalled at age 50 years and were successively attenuated for BMI recalled at ages 35 and 18 years. Weight gain in early (18-35 years of age) and mid- (35-50 years of age) adulthood was strongly associated with RCC, whereas weight gain after midlife (age 50 years to baseline) was unrelated. Waist-to hip ratio was positively associated with RCC in women and with height at age 18 years in both men and women.
在过去三十年中，美国肾细胞癌（RCC）的发病率有所上升。作者在国立卫生研究院（NIH）-美国退休人员协会饮食与健康研究中分析了体重指数（BMI）与浸润性RCC之间的关联。该研究是一项大型前瞻性队列研究，于1995 - 1996年启动，基线时年龄在50 - 71岁，随访至2003年12月。对回复第二份问卷的一个亚队列进行了详细分析，包括年轻时（18岁、35岁和50岁）的BMI；三个连续年龄区间的体重变化；腰围、臀围和腰臀比；以及18岁时的身高。共诊断出1022例男性和344例女性发生RCC。在研究基线时，RCC与BMI呈正相关且相关性很强。在亚队列中分析的受试者中，RCC与基线BMI以及50岁时回忆起的BMI关联最强，而与35岁和18岁时回忆起的BMI的相关性则依次减弱。成年早期（18 - 35岁）和中年期（35 - 50岁）体重增加与RCC密切相关，而中年后（50岁至基线）体重增加则与之无关。腰臀比在女性中与RCC呈正相关，在男性和女性中均与18岁时的身高呈正相关。
