Chitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala, NH 7, 64, Tehsil, Rajpura, Punjab, India.
NCRD's Sterling Institute of Pharmacy, Navi Mumbai, Maharastra, India.
Curr Drug Saf. 2020;15(2):82-104. doi: 10.2174/1574886315666200128095958.
Psoriasis is an autoimmune disease that ingeminates itself with the repeated proliferation of keratinocytes. It globally strikes a 2-5 % population on an average. Management of psoriasis remains a daunting task with various challenges influencing treatment, such as patient conformity and adherence to therapy, delicate patient profiles, psychological aspects, and skin as a barrier to topical delivery. The first part reviewed pathophysiology, triggering factors, and clinical classification. The second part reviewed all the therapies, such as topical, oral, biological, parenteral therapy, phototherapy, and the phyto-pharmaceuticals.
The research data related to the existing and upcoming therapies for psoriasis treatment, several nanocarriers, existing marketed formulations, and detailed description of phytopharmaceuticals with their mechanism.
Topical therapy is the mainstay treatment option with limited adverse effects. Biological therapy has reformed conventional psoriasis treatment by being more efficacious and has increased patient acceptance due to decreased adverse events. Nanoformulations present an edge over conventional therapy due to improved anti-psoriatic effect and decreased side effects. Phyto-pharmaceuticals act as a complementary and alternative therapy for diminishing psoriasis symptoms.
A rationalized cost-effective patient compliant therapy is required for effective management and complete cure of psoriasis.
银屑病是一种自身免疫性疾病，其角质形成细胞会反复增殖。平均而言，全球有 2-5%的人口受到影响。由于各种因素影响治疗，如患者的依从性和对治疗的坚持、患者的特殊情况、心理方面以及皮肤作为局部递药的屏障等，银屑病的治疗仍然是一项艰巨的任务。第一部分回顾了银屑病的病理生理学、触发因素和临床分类。第二部分综述了所有的治疗方法，如局部治疗、口服治疗、生物治疗、注射治疗、光疗和植物药。
本研究检索了与银屑病治疗的现有和新兴疗法、几种纳米载体、现有上市制剂以及植物药及其作用机制相关的数据。
局部治疗是主要的治疗选择，不良反应有限。生物疗法通过更有效和减少不良反应来提高患者的接受度，从而改变了传统的银屑病治疗方法。纳米制剂由于改善了抗银屑病作用和减少了副作用，优于传统疗法。植物药作为一种补充和替代疗法，可减轻银屑病的症状。
需要一种合理、经济、患者依从性好的治疗方法，以实现对银屑病的有效管理和完全治愈。
