异氟烷（易氟醚）暴露评估：手术室人员的环境与生物测量

Evaluation of exposure to isoflurane (Forane): environmental and biological measurements in operating room personnel.

作者信息

Imbriani M, Ghittori S, Pezzagno G, Capodaglio E

机构信息

Dipartimento di Medicina Preventiva, Occupazionale e di Comunità dell'Università di Pavia, Italy.

出版信息

J Toxicol Environ Health. 1988;25(4):393-402. doi: 10.1080/15287398809531219.

DOI:10.1080/15287398809531219

PMID:3199455

Abstract

The concentration of isoflurane (Forane) in the ambient atmosphere was determined in 11 operating theaters of 5 hospitals in Italy. The concentration of isoflurane in the ambient air exceeds the recommended time-weighted average exposure levels (median value: 113 mumol/m3). Isoflurane was detected in the urine of 45 exposed subjects (anesthetists, surgeons, and nurses). A significant correlation was found between the isoflurane concentration in urine produced during the shift (Cu' nmol/l) and isoflurane environmental concentration (Cl' mumol/m3) (Cu = 0.243 X Cl + 3.712) (r = .90). The results show that the urinary isoflurane concentration can be used as an appropriate biological exposure index. The authors suggest a biological exposure index of 18 nmol/l (3.4 micrograms/l). This is the biological value obtained after 4 h of an average environmental exposure to 81 mumol/m3 (2 ppm).

摘要

在意大利5家医院的11间手术室中测定了周围大气中异氟烷（福仑）的浓度。周围空气中异氟烷的浓度超过了推荐的时间加权平均暴露水平（中位数：113μmol/m³）。在45名暴露的受试者（麻醉师、外科医生和护士）的尿液中检测到了异氟烷。发现轮班期间产生的尿液中异氟烷浓度（Cu，nmol/l）与异氟烷环境浓度（Cl，μmol/m³）之间存在显著相关性（Cu = 0.243×Cl + 3.712）（r = 0.90）。结果表明，尿中异氟烷浓度可用作合适的生物暴露指标。作者建议生物暴露指标为18 nmol/l（3.4μg/l）。这是在平均环境暴露于81μmol/m³（2 ppm）4小时后获得的生物学值。