Universidade Federal do Amazonas, Departamento de Produção Animal e Vegetal, Manaus, AM, Brasil.
Universidade Federal do Amazonas, Departamento de Química, Manaus, AM, Brasil.
Rev Soc Bras Med Trop. 2020 Jan 27;53:e20190139. doi: 10.1590/0037-8682-0139-2019. eCollection 2020.
Leishmaniasis, a disease caused by a parasite endemic to large areas of tropical and subtropical countries, is a growing public health problem.
Male BALB/c mice were infected with Leishmania amazonensis and treated with extracts isolated from Annona mucosa.
Treated groups had significantly reduced footpad swelling. The group treated intraperitoneally with hexane extract showed footpad swelling similar to groups treated with Pentamidine® and Glucantime®. Groups treated with dichloromethane extract and hexane extract presented the recovering phenotype associated with reduced parasite levels.
Extracts of A. mucosa are promising sources of novel antileishmanial compounds.
利什曼病是一种由寄生虫引起的疾病，流行于热带和亚热带国家的大片地区，是一个日益严重的公共卫生问题。
雄性 BALB/c 小鼠感染了亚马逊利什曼原虫，并接受了从安诺那粘膜中分离出的提取物的治疗。
治疗组的足垫肿胀明显减轻。用己烷提取物腹腔内治疗的组与用戊烷脒和葡萄糖酸锑钠治疗的组的足垫肿胀相似。用二氯甲烷提取物和己烷提取物治疗的组呈现出与寄生虫水平降低相关的恢复表型。
A. mucosa 的提取物是有前途的新型抗利什曼化合物的来源。
