人血小板抗原-3 多态性作为丙型肝炎风湿表现的危险因素。
Human platelet antigen-3 polymorphism as a risk factor for rheumatological manifestations in hepatitis C.
机构信息
Universidade Estadual Paulista, Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Botucatu, SP, Brasil.
Universidade Estadual Paulista, Departamento de Bioprocessos e Biotecnologia, Faculdade de Ciências Agronômicas, Botucatu, SP, Brasil.
出版信息
Rev Soc Bras Med Trop. 2020 Jan 27;53:e20190210. doi: 10.1590/0037-8682-0210-2019. eCollection 2020.
INTRODUCTION
Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study focused on verifying associations between allele and genotype HPA and RM in patients with chronic hepatitis C.
METHODS
Patients (159) with chronic hepatitis C of both genders were analyzed.
RESULTS
Women showed association between HPA-3 polymorphisms and RM.
CONCLUSIONS
An unprecedented strong association between rheumatological manifestations and HPA-3 polymorphism, possibly predisposing women to complications during the disease course, was observed.
简介
丙型肝炎病毒（HCV）感染与自身免疫和风湿性疾病的发病机制有关。尽管人类血小板抗原（HPA）多态性与 HCV 的持续存在有关，但尚未在风湿学表现（RM）中进行研究。本研究集中于验证慢性丙型肝炎患者中 HPA 等位基因和基因型与 RM 之间的关联。
方法
分析了 159 例慢性丙型肝炎的男女患者。
结果
女性 HPA-3 多态性与 RM 之间存在关联。
结论
观察到风湿表现与 HPA-3 多态性之间存在前所未有的强关联，这可能使女性在疾病过程中易发生并发症。
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