体外鉴定近平滑念珠菌复合体各菌种的毒力因子。
In vitro characterization of virulence factors among species of the Candida parapsilosis complex.
机构信息
Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia, GO, Brasil.
Universidade Federal de Goiás, Instituto de Ciências Biológicas II, Goiânia, GO, Brasil.
出版信息
Rev Soc Bras Med Trop. 2020 Jan 27;53:e20190336. doi: 10.1590/0037-8682-0336-2019. eCollection 2020.
INTRODUCTION
Candida parapsilosis complex species differ from each other with regard to their prevalence and virulence.
METHODS
The hydrolytic enzyme activity, biofilm production, and adhesion to epithelial cells were analyzed in 87 C. parapsilosis complex strains.
RESULTS
Among the studied isolates, 97.7%, 63.2%, and 82.8% exhibited very strong proteinase, esterase, and hemolysin activity, respectively. All the C. parapsilosis complex isolates produced biofilms and presented an average adherence of 96.0 yeasts/100 epithelial cells.
CONCLUSIONS
Our results show that Candida parapsilosis complex isolates showed different levels of enzyme activity, biofilm production, and adhesion to epithelial cells.
简介
近平滑念珠菌复合种在流行程度和毒力方面存在差异。
方法
对 87 株近平滑念珠菌复合种的水解酶活性、生物膜生成和上皮细胞黏附进行了分析。
结果
在所研究的分离株中，分别有 97.7%、63.2%和 82.8%的菌株表现出很强的蛋白酶、酯酶和溶菌酶活性。近平滑念珠菌复合种所有分离株均能生成生物膜，平均黏附 100 个上皮细胞中有 96.0 个酵母细胞。
结论
我们的研究结果表明，近平滑念珠菌复合种的分离株具有不同水平的酶活性、生物膜生成和上皮细胞黏附能力。
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