Lu Jian-Zuo, Fu Jia-Xing, Wang Da-Feng, Su Zhong-Liang, Zheng Yuan-Bo
Department of Orthopedics, The People's Hospital of Wenzhou City, Wenzhou, Zhejiang, China.
J Orthop Surg (Hong Kong). 2020 Jan-Apr;28(1):2309499019900274. doi: 10.1177/2309499019900274.
The efficacy of intra-articular fentanyl supplementation for pain control after knee arthroscopy remains controversial. We conduct a systematic review and meta-analysis to explore the influence of intra-articular fentanyl supplementation for pain intensity after arthroscopic knee surgery.
We searched PubMed, EMbase, Web of Science, EBSCO, and Cochrane Library databases through May 2019 for randomized controlled trials (RCTs) assessing the efficacy and safety of intra-articular fentanyl supplementation for arthroscopic knee surgery. This meta-analysis is performed using the random-effects model.
Four RCTs are included in the meta-analysis. Overall, compared with control group after knee arthroscopy, intra-articular fentanyl supplementation is associated with reduced pain scores at 1 h (standard mean difference (Std MD) = -3.50; 95% confidence interval (CI) = -5.68 to -1.32; = 0.002), 2 h (Std MD = -4.73; 95% CI = -8.75 to -0.71; = 0.02), and 8 h (Std MD = -5.02; 95% CI = -9.73 to -0.30; = 0.04) but shows no substantial impact on pain scores at 4 h (Std MD = -3.94; 95% CI = -7.93 to 0.05; = 0.05) or the supplementary analgesia (risk ratio = 0.56; 95% CI = 0.09-3.59; = 0.54).
Intra-articular fentanyl supplementation does benefit in pain control after knee arthroscopy.
关节腔内补充芬太尼用于膝关节镜检查后疼痛控制的疗效仍存在争议。我们进行了一项系统评价和荟萃分析，以探讨关节腔内补充芬太尼对膝关节镜手术后疼痛强度的影响。
我们检索了截至2019年5月的PubMed、EMbase、Web of Science、EBSCO和Cochrane图书馆数据库，以查找评估关节腔内补充芬太尼用于膝关节镜手术的疗效和安全性的随机对照试验（RCT）。本荟萃分析采用随机效应模型进行。
荟萃分析纳入了四项RCT。总体而言，与膝关节镜检查后的对照组相比，关节腔内补充芬太尼与术后1小时（标准均数差（Std MD）=-3.
