Karasawa K
Dept. of Radiology, Social Insurance Medical Center.
Gan No Rinsho. 1988 Oct;34(13):1845-51.
At SIN (Swiss Institute for Nuclear Research) cancer treatment with negatively charged pi-mesons was initiated in 1980, and 331 patients have been treated by the end of 1987. Patients were treated in a individually-made cylindrical couch with three dimensionally optimized dynamic tumor-conforming technique (spot scanning technique). Especially for retroperitoneal and pelvic soft tissue sarcomas pions seem to be promising with 3-year local control rate 94 percent and 3-year survival rate 70 percent (15 patient, 17 manifestations). And also prostate cancers seem to be well controlled by pions without any severe complications. From these results at least for these tumors it seems worthwhile to conduct phase III prospective trials.
1980年，瑞士核研究所（SIN）开始用带负电荷的π介子进行癌症治疗，到1987年底已有331名患者接受了治疗。患者在特制的圆柱形治疗床上接受治疗，采用三维优化的动态肿瘤适形技术（点扫描技术）。特别是对于腹膜后和盆腔软组织肉瘤，π介子似乎很有前景，3年局部控制率为94%，3年生存率为70%（15例患者，17处病变）。而且前列腺癌似乎也能被π介子很好地控制，没有任何严重并发症。从这些结果来看，至少对于这些肿瘤，进行III期前瞻性试验似乎是值得的。
