Schmitt G, von Essen C F, Greiner R, Blattmann H
Radiat Res Suppl. 1985;8:S272-8.
Negative pi mesons (pions) were used to treat 227 patients at the Los Alamos Meson Production Facility (LAMPF) between 1974 and 1981. Persisting local control values for 129 patients treated with pions alone in the following tumor sites were recorded at a minimum post-treatment observation interval of 2.5 years in the following tumor sites: cerebral gliomas 3/29; head and neck, 8/31; lung, 1/7; pancreas, 0/17; large bowel, 3/13; cervix, 2/45; bladder, 3/4; prostate, 18/20; miscellaneous sites, 0/4. Late severe sequelae ranged from none to 30% for major sites. A dose-response relationship was seen for late severe sequelae with a high probability following dose levels of 4750 cGy (max) in approximately 38 fractions. RBE values for pions appeared to lie in the range of 1.4-1.6 for both acute normal tissue reactions and late sequelae. At the Swiss Institute for Nuclear Research (SIN), 126 patients were treated in Phase I-II protocol studies between 1982 and 1984 with a new technique of scanning with a focused spot of pions. With minimum observation intervals of only 6 months, the local complete response values in 67 evaluable patients treated with pions alone to selected sites are gliomas 1/15 (9 months); pancreas, 3/11; cervix, 4/8; bladder, 18/26 (at 1 year, 9/22); sarcomas, 4/5; biliary tract, 3/4. Late severe sequelae ranged from none to 50% for major sites. A steep dose-response relationship is seen for late severe sequelae with high probability following doses exceeding 3800 cGy (max) in 20 fractions and very low probability with doses below 3500 cGy (max).
1974年至1981年间，洛斯阿拉莫斯介子生产设施（LAMPF）使用负π介子（π介子）治疗了227名患者。对以下肿瘤部位仅接受π介子治疗的129名患者，在至少2.5年的治疗后观察期记录了持续局部控制值，肿瘤部位如下：脑胶质瘤3/29；头颈部，8/31；肺，1/7；胰腺，0/17；大肠，3/13；子宫颈，2/45；膀胱，3/4；前列腺，18/20；其他部位，0/4。主要部位的晚期严重后遗症发生率从无到30%不等。在约38次分割中剂量水平达到4750 cGy（最大值）后，晚期严重后遗症出现剂量反应关系的可能性很高。对于急性正常组织反应和晚期后遗症，π介子的相对生物效应值似乎在1.4 - 1.6范围内。在瑞士核研究所（SIN），1982年至1984年间，126名患者在I - II期方案研究中采用了一种新的π介子聚焦点扫描技术进行治疗。在仅6个月的最短观察期内，对选定部位仅接受π介子治疗的67名可评估患者的局部完全缓解值如下：脑胶质瘤1/15（9个月）；胰腺，3/11；子宫颈，4/8；膀胱，18/26（1年时为9/22）；肉瘤，4/5；胆道，3/4。主要部位的晚期严重后遗症发生率从无到50%不等。在20次分割中剂量超过3800 cGy（最大值）后，晚期严重后遗症出现陡峭剂量反应关系的可能性很高，而剂量低于3500 cGy（最大值）时可能性非常低。
