Greiner R, von Essen C F, Blattmann H, Studer U, Zimmermann A, Bodendoerfer G, Schmitt G
Strahlentherapie. 1985 Dec;161(12):797-800.
The experiences of the treatment of bladder carcinoma indicated the direction in which the dose optimization program of intraabdominal tumours can be carried out. Small intraabdominal target volumes seem to tolerate doses from 31 to 33 Gy applied in 20 fractions. The best results with local tumour control and low complication rates have so far been reached in carcinoma of the cervix. It has not so far been organizationally possible at SIN to treat with pions on more than four days per week. This restricts changes to the fractionation scheme in the treatment of highly malignant gliomas. An improvement of results could be possible on the basis of experience to date. The significance of a postbiopsy preoperative radiotherapy, of the increase of target volume and the increase of the total dose will be tested in a study by the SAKK (Swiss Group for Clinical Cancer Research).
膀胱癌的治疗经验为腹腔内肿瘤剂量优化方案的实施指明了方向。腹腔内较小的靶区体积似乎能够耐受20次分割给予的31至33 Gy剂量。迄今为止，宫颈癌在局部肿瘤控制和低并发症发生率方面取得了最佳效果。目前，瑞士保罗·谢尔研究所（SIN）在组织上还无法做到每周用π介子治疗超过四天。这限制了在高度恶性胶质瘤治疗中对分割方案的调整。根据目前的经验，有可能改善治疗结果。活检后术前放疗、靶区体积增加以及总剂量增加的意义将在瑞士临床癌症研究组（SAKK）的一项研究中进行测试。
