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深度测序揭示巴西亚马逊圣加布里埃尔达卡舒埃拉村居民中隐匿的曼森线虫病合并感染。

Deep Sequencing Reveals Occult Mansonellosis Coinfections in Residents From the Brazilian Amazon Village of São Gabriel da Cachoeira.

机构信息

Instituto Leônidas e Maria Deane, Fundação Oswaldo Cruz Amazônia, Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Manaus, Brazil.

Programa de Pós-graduação Stricto Sensu em Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

出版信息

Clin Infect Dis. 2020 Nov 5;71(8):1990-1993. doi: 10.1093/cid/ciaa082.

Abstract

Mansonella ozzardi and Mansonella perstans infections both cause mansonellosis but are usually treated differently. Using a real-time polymerase chain reaction assay and deep sequencing, we reveal the presence of mansonellosis coinfections that were undetectable by standard diagnostic methods. Our results confirm mansonellosis coinfections and have important implications for the disease's treatment and diagnosis.

摘要

曼氏血吸虫和曼氏裂体吸虫感染均可引起曼森线虫病,但通常采用不同的治疗方法。我们采用实时聚合酶链反应检测和深度测序技术,揭示了标准诊断方法无法检测到的曼森线虫病合并感染。我们的研究结果证实了曼森线虫病的合并感染,这对该病的治疗和诊断具有重要意义。

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