[墨西哥韦拉克鲁斯已故捐赠者肾移植后的患者生存量表]

[Patient survival scale after kidney transplant from deceased donors in Veracruz, Mexico].

作者信息

Martínez-Mier Gustavo, Soto-Miranda Ernesto, Moreno-Ley Pedro Iván, Méndez-López Marco Tulio, Budar-Fernández Luis Filadelfo, Ávila-Pardo Sandro Fabricio, Aguilar-Sandoval Edgar Guadalupe, Zilli-Hernández Stefan, Lajud-Barquín Francisco, Vega-Rojano Lucia, Coello-Torres Geovanna

机构信息

Instituto Mexicano del Seguro Social, Centro Médico Nacional “Adolfo Ruiz Cortines”, Hospital de Especialidades No. 14, Servicio de Cirugía de Trasplantes. Veracruz, Veracruz, México

出版信息

Rev Med Inst Mex Seguro Soc. 2019 May 2;57(3):149-155.

PMID:31995339

Abstract

BACKGROUND

The Estimated Post Transplant Survival (EPTS) score is calculated based on age, the presence of diabetes mellitus, years on dialysis, and prior organ transplant. The EPTS score has been validated in other countries.

OBJECTIVE

To apply and assess the EPTS score in our population of deceased-donor kidney transplants.

MATERIALS AND METHODS

Retrospective study of adult deceased-donor kidney transplants from January, 2003, to December, 2016. For the statistical analysis it was used Spearman’s correlation, receiver-operator curves (ROC) and Kaplan-Meier curves. A p value < 0.05 was considered statistically significant.

RESULTS

176 adult deceased-donor kidney transplants were included. Medium age was 34.7 ± 11 years; 53.4% were men, 4% diabetics; mean dialysis time was 5.5 ± 3.9 years and 4% had a prior organ transplant. The medium of EPTS score was 16.3 ± 18.7 (1 94). Spearman’s correlation was −0.394 (p = 0.0001). C value (ROC) was 0.64 ± 0.6 (95% CI, 0.52-0.75) (p = 0.011). Medium survival calculated with Kaplan-Meier in patients with an EPTS score < 20, was 10.2 ± 0.3 years (95% CI, 9.5-10.9) versus patients with EPTS score > 20: 7.03 ± 0.9 years (95% CI, 5.1-8.9) (p = 0.001). Each 20% increase of EPTS, patient survival time diminished (p = 0.0001).

CONCLUSIONS

The EPTS score is a useful tool for establishing survival in adult Mexican recipients of deceased-donor kidney transplants.

摘要

背景

估计移植后生存率（EPTS）评分是根据年龄、糖尿病的存在、透析年限和既往器官移植情况计算得出的。EPTS评分已在其他国家得到验证。

目的

在我们的尸体供肾移植人群中应用并评估EPTS评分。

材料与方法

对2003年1月至2016年12月的成人尸体供肾移植进行回顾性研究。统计分析采用Spearman相关性分析、受试者工作特征曲线（ROC）和Kaplan-Meier曲线。p值<0.05被认为具有统计学意义。

结果

纳入176例成人尸体供肾移植。中位年龄为34.7±11岁；53.4%为男性，4%为糖尿病患者；平均透析时间为5.5±3.9年，4%有既往器官移植史。EPTS评分中位数为16.3±18.7（1-94）。Spearman相关性为-0.394（p = 0.0001）。C值（ROC）为0.64±0.6（95%CI，0.52-0.75）（p = 0.011）。EPTS评分<20的患者，用Kaplan-Meier法计算的中位生存期为10.2±0.3年（95%CI，9.5-10.9），而EPTS评分>20的患者为7.03±0.9年（95%CI，5.1-8.9）（p = 0.001）。EPTS每增加20%，患者生存时间缩短（p = 0.0001）。