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使用MASK-air应用程序评估工作能力受损、鼻炎严重程度评分与哮喘之间的相关性。

Correlation between work impairment, scores of rhinitis severity and asthma using the MASK-air App.

作者信息

Bédard Annabelle, Antó Josep M, Fonseca Joao A, Arnavielhe Sylvie, Bachert Claus, Bedbrook Anna, Bindslev-Jensen Carsten, Bosnic-Anticevich Sinthia, Cardona Victoria, Cruz Alvaro A, Fokkens Wytske J, Garcia-Aymerich Judith, Hellings Peter W, Ivancevich Juan C, Klimek Ludger, Kuna Piotr, Kvedariene Violeta, Larenas-Linnemann Désirée, Melén Erik, Monti Ricardo, Mösges Ralf, Mullol Joaquim, Papadopoulos Nikos G, Pham-Thi Nhân, Samolinski Boleslaw, Tomazic Peter V, Toppila-Salmi Sanna, Ventura Maria Teresa, Yorgancioglu Arzu, Bousquet Jean, Pfaar Oliver, Basagaña Xavier

机构信息

ISGlobal, Barcelona, Spain.

Universitat Pompeu Fabra (UPF), Barcelona, Spain.

出版信息

Allergy. 2020 Jul;75(7):1672-1688. doi: 10.1111/all.14204. Epub 2020 Mar 22.

Abstract

BACKGROUND

In allergic rhinitis, a relevant outcome providing information on the effectiveness of interventions is needed. In MASK-air (Mobile Airways Sentinel Network), a visual analogue scale (VAS) for work is used as a relevant outcome. This study aimed to assess the performance of the work VAS work by comparing VAS work with other VAS measurements and symptom-medication scores obtained concurrently.

METHODS

All consecutive MASK-air users in 23 countries from 1 June 2016 to 31 October 2018 were included (14 189 users; 205 904 days). Geolocalized users self-assessed daily symptom control using the touchscreen functionality on their smart phone to click on VAS scores (ranging from 0 to 100) for overall symptoms (global), nose, eyes, asthma and work. Two symptom-medication scores were used: the modified EAACI CSMS score and the MASK control score for rhinitis. To assess data quality, the intra-individual response variability (IRV) index was calculated.

RESULTS

A strong correlation was observed between VAS work and other VAS. The highest levels for correlation with VAS work and variance explained in VAS work were found with VAS global, followed by VAS nose, eye and asthma. In comparison with VAS global, the mCSMS and MASK control score showed a lower correlation with VAS work. Results are unlikely to be explained by a low quality of data arising from repeated VAS measures.

CONCLUSIONS

VAS work correlates with other outcomes (VAS global, nose, eye and asthma) but less well with a symptom-medication score. VAS work should be considered as a potentially useful AR outcome in intervention studies.

摘要

背景

在变应性鼻炎中,需要一个能提供干预效果信息的相关结局指标。在MASK-air(移动气道哨兵网络)中,工作视觉模拟量表(VAS)被用作一个相关结局指标。本研究旨在通过比较工作VAS与其他VAS测量值以及同时获得的症状-药物评分,来评估工作VAS的性能。

方法

纳入2016年6月1日至2018年10月31日期间23个国家所有连续的MASK-air用户(14189名用户;205904天)。通过地理定位的用户使用智能手机上的触摸屏功能,针对总体症状(全球)、鼻子、眼睛、哮喘和工作,点击VAS评分(范围为0至100),进行每日症状控制的自我评估。使用了两个症状-药物评分:改良的欧洲变态反应和临床免疫学会(EAACI)症状-药物评分系统(CSMS)分数以及鼻炎的MASK控制分数。为评估数据质量,计算了个体内反应变异性(IRV)指数。

结果

观察到工作VAS与其他VAS之间存在强相关性。与工作VAS相关性最高且能解释工作VAS方差的是全球VAS,其次是鼻子、眼睛和哮喘的VAS。与全球VAS相比,改良的EAACI CSMS分数和MASK控制分数与工作VAS的相关性较低。结果不太可能由重复VAS测量产生的低质量数据来解释。

结论

工作VAS与其他结局指标(全球VAS、鼻子、眼睛和哮喘VAS)相关,但与症状-药物评分的相关性较差。在干预研究中,工作VAS应被视为一个潜在有用的变应性鼻炎结局指标。

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