APC, LLC, Ankeny, IA, USA.
APC, Europe, S.L.U., Granollers, Barcelona, Spain.
Transbound Emerg Dis. 2020 May;67(3):1101-1112. doi: 10.1111/tbed.13496. Epub 2020 Feb 16.
The introduction and spread of porcine epidemic diarrhoea virus (PEDV) in North America resulted in significant death loss in the swine industry. As the industry learned how to manage this disease, many new risks were identified, including the potential for feed and feed ingredients to become contaminated and spread PEDV. In addition, biosecurity practices were reevaluated and strengthened throughout the industry. At the time of the outbreak epidemiologists did not understand, as well as they are understood today, all the risk factors that contribute to the spread of PEDV. As a result, the epidemiological investigations into the 2014 PEDV outbreak in eastern Canada may not have investigated all risk factors as thoroughly as they would be investigated today. In retrospect, many of the Bradford Hill criteria used to determine causation were not fulfilled. This review identifies risk factors that were not included in the 2014 epidemiology. If these risk factors were included in the epidemiology, the conclusions and determination of causation may have been different.
猪流行性腹泻病毒（PEDV）在北美的引入和传播导致了养猪业的重大死亡损失。随着该行业学会了如何管理这种疾病，许多新的风险被识别出来，包括饲料和饲料成分可能受到污染并传播 PEDV 的风险。此外，整个行业都重新评估和加强了生物安全措施。在疫情爆发时，流行病学家并不像今天这样了解所有导致 PEDV 传播的风险因素。因此，对加拿大东部 2014 年 PEDV 爆发的流行病学调查可能没有像今天这样彻底调查所有风险因素。回想起来，用于确定因果关系的许多布拉德福德·希尔标准都没有得到满足。本综述确定了未包含在 2014 年流行病学中的风险因素。如果这些风险因素包含在流行病学中，结论和因果关系的确定可能会有所不同。
