School of Medicine, University of Auckland, Auckland, New Zealand.
Expert Rev Gastroenterol Hepatol. 2020 Feb;14(2):103-111. doi: 10.1080/17474124.2020.1718492. Epub 2020 Jan 30.
: Motilin was first alluded to nearly a century ago. But it remains a rather abstruse peptide, in the shadow of its younger but more lucid 'cousin' ghrelin.: The review aimed to bring to the fore multifarious aspects of motilin research with a view to aiding prioritization of future studies on this gastrointestinal peptide.: Growing evidence indicates that rodents (mice, rats, guinea pigs) do not have functional motilin system and, hence, studies in these species are likely to have a minimal translational impact. Both the active peptide and motilin receptor were initially localized to the upper gastrointestinal tract only but more recently - also to the brain (in both humans and other mammals with functional motilin system). Motilin is now indisputably implicated in interdigestive contractile activity of the gastrointestinal tract (in particular, gastric phase III of the migrating motor complex). Beyond this role, evidence is building that there is a cross-talk between motilin system and the brain-pancreas axis, suggesting that motilin exerts not only contractile but also orexigenic and insulin secretagogue actions.
胃动素早在近一个世纪前就被提及。但它仍然是一种相当深奥的肽，其年轻但更清晰的“表亲”胃饥饿素在其阴影之下。
本次综述旨在突出胃动素研究的多方面，以期有助于对这种胃肠道肽的未来研究进行优先排序。
越来越多的证据表明，啮齿动物（小鼠、大鼠、豚鼠）没有功能性的胃动素系统，因此，这些物种的研究可能具有最小的转化影响。活性肽和胃动素受体最初仅定位于上胃肠道，但最近也定位于大脑（在具有功能性胃动素系统的人类和其他哺乳动物中）。胃动素现在无疑与胃肠道的消化间期收缩活动有关（特别是移行性运动复合波的胃期 III）。除了这个作用之外，还有证据表明胃动素系统与脑-胰腺轴之间存在交叉对话，这表明胃动素不仅具有收缩作用，而且还具有食欲刺激和胰岛素分泌作用。
