Freerksen E, Rosenfeld M, Freerksen R, Krüger-Thiemer M
Chemotherapy. 1977;23(3):192-210. doi: 10.1159/000221987.
The present stage of our studies suggests that, provided a highly effective combined therapy is, and can be, carried out correctly, all excreters can be cured of their chronic carrier state by chemotherapy within 8-12 weeks. Although we cannot recommend a universal therapeutic regimen for all patients, a highly effective 'basic therapy' (RMP+TSP) is available for the majority of the cases, needing occasional modification, depending on the specific requirements of the individual patient as shown by the result of the serum activity determination. This method saves the patient from toxic inconveniences caused by inadequate treatment, it shortens the treatment time and makes cholecystectomy superfluous - unless it is considered necessary out of a different indication in which case it should certainly be done. We cannot share the often expressed view that Salmonella enteritidis excreters cannot be cured, a view which is found even in the most recent manuals. The same applies to the view that therapy is not necessary because it would delay cure. It is indispensable to establish a close cooperation between the public health authorities and the private physician, and we therefore wish to sincerely thank all colleagues and Public Health Officers for their collaboration.
我们现阶段的研究表明，倘若能正确实施且确实实施了高效的联合治疗，那么所有排泄物带菌者都可在8至12周内通过化疗治愈其慢性带菌状态。虽然我们无法为所有患者推荐通用的治疗方案，但对于大多数病例而言，有一种高效的“基础治疗”（利福平+硫柳汞）可供使用，不过需根据血清活性测定结果所显示的个体患者的具体需求，偶尔进行调整。这种方法可使患者免受因治疗不当而产生的毒性不便，缩短治疗时间，并且使胆囊切除术变得多余——除非出于其他不同指征而认为有必要进行，在这种情况下当然应该实施。我们不能认同那种常被表达的观点，即肠炎沙门氏菌排泄物带菌者无法治愈，这种观点甚至在最新的手册中也能找到。那种认为治疗没必要，因为它会延迟治愈的观点同样站不住脚。公共卫生当局与私人医生之间建立密切合作是必不可少的，因此我们由衷感谢所有同事和公共卫生官员的协作。
