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cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas.

作者信息

Brat Daniel J, Aldape Kenneth, Colman Howard, Figrarella-Branger Dominique, Fuller Gregory N, Giannini Caterina, Holland Eric C, Jenkins Robert B, Kleinschmidt-DeMasters Bette, Komori Takashi, Kros Johan M, Louis David N, McLean Catriona, Perry Arie, Reifenberger Guido, Sarkar Chitra, Stupp Roger, van den Bent Martin J, von Deimling Andreas, Weller Michael

机构信息

Department of Pathology, Robert H. Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Ward Building, 3-140, 303 E. Chicago Ave, Chicago, IL, 60611, USA.

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

出版信息

Acta Neuropathol. 2020 Mar;139(3):603-608. doi: 10.1007/s00401-020-02127-9. Epub 2020 Jan 29.

Abstract
摘要

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CDKN2A homozygous deletion is a strong adverse prognosis factor in diffuse malignant IDH-mutant gliomas.
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FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas.
Acta Neuropathol. 2020 Jan;139(1):175-192. doi: 10.1007/s00401-019-02067-z. Epub 2019 Aug 31.
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MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.
Cancer Res. 2019 Jul 1;79(13):3383-3394. doi: 10.1158/0008-5472.CAN-18-1010. Epub 2019 Apr 30.
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Integrated molecular characterization of IDH-mutant glioblastomas.
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