Sörensen Ben M, van der Heide Frank C T, Houben Alfons J H M, Koster Annemarie, T J M Berendschot Tos, S A G Schouten Jan, Kroon Abraham A, van der Kallen Carla J H, Henry Ronald M A, van Dongen Martien C J M, J P M Eussen Simone, H C M Savelberg Hans, van der Berg Julianne D, Schaper Nicolaas C, Schram Miranda T, Stehouwer Coen D A
CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.
Department of Internal Medicine, Maastricht University Medical Center+, Maastricht, The Netherlands.
Microcirculation. 2020 May;27(4):e12611. doi: 10.1111/micc.12611. Epub 2020 Mar 10.
Physical activity may provide a means for the prevention of cardiovascular disease via improving microvascular function. Therefore, this study investigated whether physical activity is associated with skin and retinal microvascular function.
In The Maastricht Study, a population-based cohort study enriched with type 2 diabetes (n = 1298, 47.3% women, aged 60.2 ± 8.1 years, 29.5% type 2 diabetes), we studied whether accelerometer-assessed physical activity and sedentary time associate with skin and retinal microvascular function. Associations were studied by linear regression and adjusted for major cardiovascular risk factors. In addition, we investigated whether associations were stronger in type 2 diabetes.
In individuals with type 2 diabetes, total physical activity and higher-intensity physical activity were independently associated with greater heat-induced skin hyperemia (regression coefficients per hour), respectively, 10 (95% CI: 1; 18) and 36 perfusion units (14; 58). In individuals without type 2 diabetes, total physical activity and higher-intensity physical activity were not associated with heat-induced skin hyperemia. No associations with retinal arteriolar %-dilation were identified.
Higher levels of total and higher-intensity physical activity were associated with greater skin microvascular vasodilation in individuals with, but not in those without, type 2 diabetes.
体育活动可能通过改善微血管功能为预防心血管疾病提供一种方法。因此，本研究调查了体育活动是否与皮肤和视网膜微血管功能相关。
在马斯特里赫特研究中，这是一项以人群为基础的队列研究，纳入了2型糖尿病患者（n = 1298，47.3%为女性，年龄60.2±8.1岁，29.5%为2型糖尿病患者），我们研究了通过加速度计评估的体育活动和久坐时间是否与皮肤和视网膜微血管功能相关。通过线性回归研究相关性，并对主要心血管危险因素进行校正。此外，我们还研究了在2型糖尿病患者中相关性是否更强。
在2型糖尿病患者中，总体育活动量和高强度体育活动分别与更大的热诱导皮肤充血独立相关（每小时回归系数），分别为10（95%CI：1；18）和36灌注单位（14；58）。在无2型糖尿病的个体中，总体育活动量和高强度体育活动与热诱导皮肤充血无关。未发现与视网膜小动脉%-扩张有关联。
在2型糖尿病患者中，较高水平的总体育活动量和高强度体育活动与更大的皮肤微血管舒张相关，但在无2型糖尿病的个体中则不然。
