Mirnezami Mina, Jafarimanesh Hadi, Rezagholizamenjany Masoud, Alimoradian Abbas, Ranjbaran Mehdi
Department of Dermatology, Arak University of Medical Sciences, Arak, Iran.
Department of Nursing, Arak University of Medical Sciences, Arak, Iran.
Dermatol Ther. 2020 Mar;33(2):e13236. doi: 10.1111/dth.13236. Epub 2020 Feb 10.
The aim of the present study was to investigate the effect of silymarin (Livergol) on liver enzymes in patients taking isotretinoin (Roaccutane). In this double-blind clinical trial, 74 patients with acne and taking isotretinoin were randomly assigned into intervention (N = 37) and control (N = 37) groups. The intervention group received a 140 mg Livergol capsule per day for 30 days. The control group received a starch-containing capsule as a placebo once a day for 30 days. Liver enzyme levels were measured before and after the intervention. The data were analyzed using chi-square test, Independent t test, paired sample t test and analysis of covariance (ANCOVA). The results showed no statistically significant difference between the intervention and control groups at the beginning of study in levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) (p > .05). At the end of the study, a statistically significant difference was observed between the two groups in levels of AST and ALT (p < .05). Livergol prevented liver enzymes from increasing, so it can be used as an effective, low-cost, and low-complication treatment for the problem of increased levels of liver enzymes following the use of isotretinoin.
本研究的目的是调查水飞蓟素（利肝隆）对服用异维A酸（保肤灵）患者肝脏酶的影响。在这项双盲临床试验中，74名患有痤疮且正在服用异维A酸的患者被随机分为干预组（N = 37）和对照组（N = 37）。干预组每天服用140毫克利肝隆胶囊，持续30天。对照组每天服用一次含淀粉胶囊作为安慰剂，持续30天。在干预前后测量肝脏酶水平。数据采用卡方检验、独立样本t检验、配对样本t检验和协方差分析（ANCOVA）进行分析。结果显示，在研究开始时，干预组和对照组之间的天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）和碱性磷酸酶（ALP）水平无统计学显著差异（p > 0.05）。在研究结束时，两组之间的AST和ALT水平存在统计学显著差异（p < 0.05）。利肝隆可防止肝脏酶升高，因此它可作为一种有效、低成本且低并发症的治疗方法，用于解决使用异维A酸后肝脏酶水平升高的问题。
