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2019 年,良性输尿管狭窄的球囊扩张术是否仍有作用?

Is there still a role of balloon dilatation of benign ureteric strictures in 2019?

机构信息

Department of Urology, Changi General Hospital, Singapore, Singapore.

Department of Radiology, Changi General Hospital, Singapore, Singapore.

出版信息

Scand J Urol. 2020 Feb;54(1):80-85. doi: 10.1080/21681805.2020.1716845. Epub 2020 Jan 30.

Abstract

Reconstructive surgery for benign ureteric strictures and long term nephrostomy are often invasive and lead to poor quality of life. Balloon dilatation has the potential to bridge this gap. We present the outcome of our series and examine the risk factors of stricture recurrence. There were 109 strictures in our series from August 2012 to July 2018 in our single center retrospective cohort analysis. All strictures were dilated retrogradely or antegradely and followed by stenting. Follow-up imaging was done to assess stricture recurrence. Mean patient age was 57.7-years-old (SD ± 12.6). Mean follow-up was 20.2 months (SE ± 1.8). All strictures were successfully dilated and stented. Overall, mean patency rate was 63.7% at mean follow-up of 20.2 months (SE ± 1.8). Strictures caused by stone/inflammation had 28.0% (21/75) risk of recurrence compared to iatrogenic causes, 63.6% (7/11), and radiotherapy, 100.0% (5/5) ( = 0.001). Non-incidental strictures also had significantly higher risk of recurrence at 57.4% (27/47) vs. incidental strictures at 13.6% (6/44) ( = 0.000). The mean length of strictures was 12.5 mm (SE ± 1.7) in the recurrence group vs. 9.6 mm (SE ± 0.7) in those without recurrence ( = 0.001). The presence of ipsilateral atrophic kidney was associated with 72.2% (13/18) risk of recurrence vs. non-atrophic kidney 27.4% (20/73) ( = 0.000). The mean age of stricture was 14.5 months (SE ± 4.6) and 5.2 months (SE ± 2.1) in the recurrence and non-recurrence groups, respectively ( = 0.013). Balloon dilatation of benign ureteric stricture is a feasible option. Its effect can be long-lasting in selected patients, that is, non-irradiated, incidental, short strictures with normal kidneys. This will benefit patients unfit for reconstructive surgery.

摘要

良性输尿管狭窄的重建手术和长期肾造口术往往具有侵入性,导致生活质量下降。球囊扩张有可能填补这一空白。我们展示了我们的系列研究结果,并研究了狭窄复发的危险因素。在我们的单中心回顾性队列分析中,我们在 2012 年 8 月至 2018 年 7 月期间共发现 109 例狭窄。所有狭窄均经逆行或顺行扩张,并随后进行支架置入。进行随访影像学检查以评估狭窄复发情况。患者平均年龄为 57.7 岁(标准差 ± 12.6)。平均随访时间为 20.2 个月(标准误差 ± 1.8)。所有狭窄均成功扩张并置入支架。总的来说,在平均 20.2 个月(标准误差 ± 1.8)的随访中,总体通畅率为 63.7%(21/75)。由结石/炎症引起的狭窄复发风险为 28.0%(21/75),而医源性狭窄为 63.6%(7/11),放疗为 100.0%(5/5)(=0.001)。非偶然狭窄的复发风险也显著更高,为 57.4%(27/47),而偶然狭窄的复发风险为 13.6%(6/44)(=0.000)。复发组狭窄的平均长度为 12.5 毫米(标准误差 ± 1.7),而无复发组为 9.6 毫米(标准误差 ± 0.7)(=0.001)。同侧萎缩性肾脏与 72.2%(13/18)的复发风险相关,而非萎缩性肾脏为 27.4%(20/73)(=0.000)。狭窄的平均年龄为 14.5 个月(标准误差 ± 4.6)和 5.2 个月(标准误差 ± 2.1),分别在复发组和无复发组(=0.013)。球囊扩张治疗良性输尿管狭窄是一种可行的选择。在选择的患者中,这种治疗效果可能是持久的,即非放疗、非偶然、狭窄较短且肾脏正常的患者。这将使不适合重建手术的患者受益。

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