Department of Genetics, Barkatullah University, Bhopal, Madhya Pradesh, India.
Adv Protein Chem Struct Biol. 2020;119:199-245. doi: 10.1016/bs.apcsb.2019.09.004. Epub 2019 Nov 26.
During the 19th century, for the first time, the linkage between inflammation and cancer was established. Inflammatory microenvironment is an essential component of the tumor microenvironment. Chronic inflammation due to persistent infection due to the microbes, viruses, helminths or constant exposure to non-infectious factors like smoke, silica or asbestos eventually might result in carcinogenesis. In tumor microenvironment, various inflammatory cells such as T lymphocytes (occasionally B cells), dendritic cells, macrophages, monocytes, neutrophils and natural killer (NK) cells are present. As a mediator of immune surveillance and host defense TRAIL cytokines are produced which upon binding with death receptors (DRs) initiate a cascade of apoptotic pathways. Anti-inflammatory drugs such as aspirin, celecoxib, diclofenac, diflunisal and ibuprofen etc. are being used against cancer, indicating the interplay between both the mechanisms. A deeper understanding of common pathways implicated between both the inflammation and cancer may pave the way to fight against both of these deleterious ailments.
19 世纪，人们首次发现炎症与癌症之间存在关联。炎症微环境是肿瘤微环境的重要组成部分。由于微生物、病毒、寄生虫的持续感染，或由于长期暴露于非传染性因素（如烟、二氧化硅或石棉），慢性炎症最终可能导致癌变。在肿瘤微环境中，存在各种炎性细胞，如 T 淋巴细胞（偶尔 B 细胞）、树突状细胞、巨噬细胞、单核细胞、中性粒细胞和自然杀伤（NK）细胞。TRAIL 细胞因子作为免疫监视和宿主防御的介质被产生，与死亡受体（DR）结合后，启动凋亡途径的级联反应。阿司匹林、塞来昔布、双氯芬酸、二氟尼柳和布洛芬等抗炎药被用于抗癌，表明这两种机制之间存在相互作用。深入了解炎症和癌症之间共同涉及的途径，可能为对抗这两种有害疾病铺平道路。
