LIM kinases in synaptic plasticity and their potential as therapeutic targets.
作者信息
Halasz Eva, Townes-Anderson Ellen, Wang Weiwei
机构信息
Department of Pharmacology, Physiology and Neuroscience, Graduate School of Biomedical Sciences, Rutgers, The State University of New Jersey, Newark, NJ, USA.
Grousbeck Gene Therapy Center, Schepens Eye Research Institute and Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
出版信息
Neural Regen Res. 2020 Aug;15(8):1471-1472. doi: 10.4103/1673-5374.274333.
Abstract
摘要
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LIM kinases in synaptic plasticity and their potential as therapeutic targets.LIM激酶在突触可塑性中的作用及其作为治疗靶点的潜力。
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Actin Dynamics, Regulated by RhoA-LIMK-Cofilin Signaling, Mediates Rod Photoreceptor Axonal Retraction After Retinal Injury.肌动蛋白动态变化受 RhoA-LIMK-Cofilin 信号调控，介导视网膜损伤后 rod 光感受器轴突回缩。
Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2274-2285. doi: 10.1167/iovs.18-26077.
2
PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior.PAK2 杂合不足导致突触细胞骨架损伤和自闭症相关行为。
Cell Rep. 2018 Aug 21;24(8):2029-2041. doi: 10.1016/j.celrep.2018.07.061.
3
Antagomirs Targeting MicroRNA-134 Increase Limk1 Levels After Experimental Seizures in Vitro and in Vivo.靶向微小RNA-134的抗反义寡核苷酸在体外和体内实验性癫痫发作后可提高Limk1水平。
Cell Physiol Biochem. 2017;43(2):636-643. doi: 10.1159/000480647. Epub 2017 Sep 22.
4
Electroacupuncture Regulates Hippocampal Synaptic Plasticity via miR-134-Mediated LIMK1 Function in Rats with Ischemic Stroke.电针通过miR-134介导的LIMK1功能调节缺血性脑卒中大鼠的海马突触可塑性
Neural Plast. 2017;2017:9545646. doi: 10.1155/2017/9545646. Epub 2017 Jan 2.
5
Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction.海马 LIMK 抑制对记忆获取、巩固、检索、再巩固和遗忘的影响。
Mol Neurobiol. 2018 Feb;55(2):958-967. doi: 10.1007/s12035-016-0361-x. Epub 2017 Jan 13.
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Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization.神经连接蛋白1通过LIMK1/丝切蛋白介导的肌动蛋白重组来调节棘突和突触可塑性。
J Cell Biol. 2016 Feb 15;212(4):449-63. doi: 10.1083/jcb.201509023.
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LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury.LIM激酶，一种新发现的损伤后视杆光感受器突触前重塑的调节因子。
Invest Ophthalmol Vis Sci. 2015 Dec;56(13):7847-58. doi: 10.1167/iovs.15-17278.
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Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and morphological plasticity.LIM激酶-1的棕榈酰化作用确保了树突棘特异性肌动蛋白聚合和形态可塑性。
Elife. 2015 Apr 17;4:e06327. doi: 10.7554/eLife.06327.
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Photoreceptor ablation initiates the immediate loss of glutamate receptors in postsynaptic bipolar cells in retina.光感受器消融会导致视网膜中突触后双极细胞立即丧失谷氨酸受体。
J Neurosci. 2015 Feb 11;35(6):2423-31. doi: 10.1523/JNEUROSCI.4284-14.2015.
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LIMK1 regulates long-term memory and synaptic plasticity via the transcriptional factor CREB.LIMK1通过转录因子CREB调节长期记忆和突触可塑性。
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