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1
LIM kinases in synaptic plasticity and their potential as therapeutic targets.LIM激酶在突触可塑性中的作用及其作为治疗靶点的潜力。
Neural Regen Res. 2020 Aug;15(8):1471-1472. doi: 10.4103/1673-5374.274333.
2
Roles of LIM kinases in central nervous system function and dysfunction.LIM激酶在中枢神经系统功能与功能障碍中的作用。
FEBS Lett. 2015 Dec 21;589(24 Pt B):3795-806. doi: 10.1016/j.febslet.2015.10.032. Epub 2015 Nov 3.
3
Electroacupuncture Regulates Hippocampal Synaptic Plasticity via miR-134-Mediated LIMK1 Function in Rats with Ischemic Stroke.电针通过miR-134介导的LIMK1功能调节缺血性脑卒中大鼠的海马突触可塑性
Neural Plast. 2017;2017:9545646. doi: 10.1155/2017/9545646. Epub 2017 Jan 2.
4
LIM kinases: cofilin and beyond.LIM激酶：丝切蛋白及其他
Oncotarget. 2017 Jun 20;8(25):41749-41763. doi: 10.18632/oncotarget.16978.
5
Modulation of neurotransmitter release by the second messenger-activated protein kinases: implications for presynaptic plasticity.第二信使激活的蛋白激酶对神经递质释放的调节：对突触前可塑性的影响
Pharmacol Ther. 2005 Jan;105(1):69-84. doi: 10.1016/j.pharmthera.2004.10.012.
6
Lim kinase, a bi-functional effector in injury-induced structural plasticity of synapses.LIM激酶，一种在损伤诱导的突触结构可塑性中起双功能作用的效应器。
Neural Regen Res. 2016 Jul;11(7):1029-32. doi: 10.4103/1673-5374.187018.
7
LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators.LIM 激酶与许多大分子伴侣相互作用，而小分子调节剂却很少，因此成为一个有吸引力的靶标。
Med Res Rev. 2012 Sep;32(5):968-98. doi: 10.1002/med.20230. Epub 2011 Jan 16.
8
The p75 Neurotrophin Receptor Is an Essential Mediator of Impairments in Hippocampal-Dependent Associative Plasticity and Memory Induced by Sleep Deprivation.p75 神经营养因子受体是睡眠剥夺诱导的海马依赖性联想性可塑性和记忆损伤的必需介质。
J Neurosci. 2019 Jul 10;39(28):5452-5465. doi: 10.1523/JNEUROSCI.2876-18.2019. Epub 2019 May 13.
9
Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases.环磷酸腺苷依赖性蛋白激酶对海马突触可塑性的调节
Prog Neurobiol. 2003 Dec;71(6):401-37. doi: 10.1016/j.pneurobio.2003.12.003.
10
Comparative analysis of splice form-specific expression of LIM Kinases during zebrafish development.斑马鱼发育过程中LIM激酶剪接形式特异性表达的比较分析。
Gene Expr Patterns. 2007 Apr;7(5):620-9. doi: 10.1016/j.modgep.2006.12.005. Epub 2006 Dec 29.

引用本文的文献

1
LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features.LIM 激酶，LIMK1 和 LIMK2，是细胞命运的关键节点作用因子：从分子到病理特征。
Cells. 2023 Mar 4;12(5):805. doi: 10.3390/cells12050805.

本文引用的文献

1
Actin Dynamics, Regulated by RhoA-LIMK-Cofilin Signaling, Mediates Rod Photoreceptor Axonal Retraction After Retinal Injury.肌动蛋白动态变化受 RhoA-LIMK-Cofilin 信号调控，介导视网膜损伤后 rod 光感受器轴突回缩。
Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2274-2285. doi: 10.1167/iovs.18-26077.
2
PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior.PAK2 杂合不足导致突触细胞骨架损伤和自闭症相关行为。
Cell Rep. 2018 Aug 21;24(8):2029-2041. doi: 10.1016/j.celrep.2018.07.061.
3
Antagomirs Targeting MicroRNA-134 Increase Limk1 Levels After Experimental Seizures in Vitro and in Vivo.靶向微小RNA-134的抗反义寡核苷酸在体外和体内实验性癫痫发作后可提高Limk1水平。
Cell Physiol Biochem. 2017;43(2):636-643. doi: 10.1159/000480647. Epub 2017 Sep 22.
4
Electroacupuncture Regulates Hippocampal Synaptic Plasticity via miR-134-Mediated LIMK1 Function in Rats with Ischemic Stroke.电针通过miR-134介导的LIMK1功能调节缺血性脑卒中大鼠的海马突触可塑性
Neural Plast. 2017;2017:9545646. doi: 10.1155/2017/9545646. Epub 2017 Jan 2.
5
Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction.海马 LIMK 抑制对记忆获取、巩固、检索、再巩固和遗忘的影响。
Mol Neurobiol. 2018 Feb;55(2):958-967. doi: 10.1007/s12035-016-0361-x. Epub 2017 Jan 13.
6
Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization.神经连接蛋白1通过LIMK1/丝切蛋白介导的肌动蛋白重组来调节棘突和突触可塑性。
J Cell Biol. 2016 Feb 15;212(4):449-63. doi: 10.1083/jcb.201509023.
7
LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury.LIM激酶，一种新发现的损伤后视杆光感受器突触前重塑的调节因子。
Invest Ophthalmol Vis Sci. 2015 Dec;56(13):7847-58. doi: 10.1167/iovs.15-17278.
8
Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and morphological plasticity.LIM激酶-1的棕榈酰化作用确保了树突棘特异性肌动蛋白聚合和形态可塑性。
Elife. 2015 Apr 17;4:e06327. doi: 10.7554/eLife.06327.
9
Photoreceptor ablation initiates the immediate loss of glutamate receptors in postsynaptic bipolar cells in retina.光感受器消融会导致视网膜中突触后双极细胞立即丧失谷氨酸受体。
J Neurosci. 2015 Feb 11;35(6):2423-31. doi: 10.1523/JNEUROSCI.4284-14.2015.
10
LIMK1 regulates long-term memory and synaptic plasticity via the transcriptional factor CREB.LIMK1通过转录因子CREB调节长期记忆和突触可塑性。
Mol Cell Biol. 2015 Apr;35(8):1316-28. doi: 10.1128/MCB.01263-14. Epub 2015 Feb 2.

LIM kinases in synaptic plasticity and their potential as therapeutic targets.

作者信息

Halasz Eva, Townes-Anderson Ellen, Wang Weiwei

机构信息

Department of Pharmacology, Physiology and Neuroscience, Graduate School of Biomedical Sciences, Rutgers, The State University of New Jersey, Newark, NJ, USA.

Grousbeck Gene Therapy Center, Schepens Eye Research Institute and Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

出版信息

Neural Regen Res. 2020 Aug;15(8):1471-1472. doi: 10.4103/1673-5374.274333.

DOI:10.4103/1673-5374.274333
PMID:31997806
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7059582/
Abstract
摘要