Yavuz Goknur Ozaydın, Yavuz Ibrahim Halil, Bayram Irfan, Aktar Rojda, Bilgili Serap Gunes
Department of Dermatology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey.
Department of Pathology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey.
Postepy Dermatol Alergol. 2019 Dec;36(6):739-743. doi: 10.5114/ada.2018.77726. Epub 2018 Aug 21.
Lupus erythematosus (LE) is an autoimmune disease characterized by a broad range of cutaneous manifestations. Discoid LE (DLE) is the most common chronic manifestation of LE. Literature reviews show that there are a limited number of large-series studies investigating DLE. Additionally, there is still no consensus on the etiological factors of DLE such as sun exposure and smoking.
To evaluate the clinical and demographic characteristics of patients with DLE.
The study included patients who were hospitalized in the inpatient and outpatient clinics at the Dermatology Department. Age, gender, treatment method, history of smoking, antinuclear antibody positivity, progression to systemic lupus erythematosus (SLE), photosensitivity, and laboratory findings were recorded for each patient.
The study included 132 patients comprising 67 (50.8%) men and 65 (49.2%) women. A family history was found in 3.8%, SLE was detected in 5.3%, and photosensitivity was revealed in 50.0% of the patients. ANA positivity was found in 23.7%, a history of smoking was revealed in 61.4%, and chronic sun exposure was detected in 42.4% of the patients.
Discoid LE, though identified long ago, remains unelucidated and there are very few studies in the literature reporting on DLE. The results indicated that smoking and chronic UV exposure are important risk factors for DLE. Moreover, although ANA positivity was high in our patients, the rate of progression to SLE was remarkably low. The results also showed that, contrary to common belief, there is no female preponderance in DLE.
红斑狼疮（LE）是一种自身免疫性疾病，其特征为广泛的皮肤表现。盘状红斑狼疮（DLE）是LE最常见的慢性表现。文献综述表明，研究DLE的大型系列研究数量有限。此外，关于DLE的病因因素，如日晒和吸烟，仍未达成共识。
评估DLE患者的临床和人口统计学特征。
该研究纳入了在皮肤科住院和门诊就诊的患者。记录每位患者的年龄、性别、治疗方法、吸烟史、抗核抗体阳性情况、发展为系统性红斑狼疮（SLE）的情况、光敏性以及实验室检查结果。
该研究纳入了132例患者，其中男性67例（50.8%），女性65例（49.2%）。3.8%的患者有家族病史，5.3%的患者检测出SLE，50.0%的患者有光敏性。23.7%的患者抗核抗体阳性，61.4%的患者有吸烟史，42.4%的患者有长期日晒史。
盘状红斑狼疮虽然早在很久以前就已被发现，但仍未完全阐明，文献中关于DLE的研究非常少。结果表明，吸烟和长期紫外线暴露是DLE的重要危险因素。此外，尽管我们的患者中抗核抗体阳性率较高，但发展为SLE的比例非常低。结果还表明，与普遍看法相反，DLE并无女性优势。
