Wang Qiong, Liu Yingjuan, Zhang Jianxu, Wang Weiwen
School of Education, Zhengzhou University, Zhengzhou, China.
School of Life Sciences and Technology, Nanyang Normal University, Nanyang, China.
Front Psychol. 2020 Jan 10;10:3028. doi: 10.3389/fpsyg.2019.03028. eCollection 2019.
Stress inoculation has been proved to induce active coping behaviors to subsequent stress. However, the specific neural mechanisms underlying this effect remain unclear. In this study, a chronic and mild predator odor exposure model was established to investigate the effect of predator odor stress inoculation on behaviors in novel predator odor exposure, open field test and forced swimming test (FST), and on the expression of CRF receptors in locus coeruleus (LC) and dorsal raphe nuclei (DRN). The results showed that predator odor stress inoculation increased the active coping of mice under the severe stress environment without changing the stress response to a new predator odor. Meanwhile, in LC, the CRFR1 expression was increased by predator odor stress inoculation. These results suggested that predator odor stress inoculation can be used as an effective training method to improve active response to later severe stress and the function of CRFR1 in LC might be a potential underlying biological mechanism.
应激接种已被证明能诱导对后续应激产生积极的应对行为。然而，这种效应背后的具体神经机制仍不清楚。在本研究中，建立了一种慢性轻度捕食者气味暴露模型，以研究捕食者气味应激接种对新奇捕食者气味暴露、旷场试验和强迫游泳试验（FST）中行为的影响，以及对蓝斑（LC）和中缝背核（DRN）中促肾上腺皮质激素释放因子（CRF）受体表达的影响。结果表明，捕食者气味应激接种增加了小鼠在严重应激环境下的积极应对，而不改变对新捕食者气味的应激反应。同时，在LC中，捕食者气味应激接种增加了CRFR1的表达。这些结果表明，捕食者气味应激接种可作为一种有效的训练方法，以改善对后期严重应激的积极反应，且LC中CRFR1的功能可能是潜在的生物学机制。
